{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:56:01Z","timestamp":1791417361720,"version":"4.3.3"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008564","name":"Norges Blindeforbund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Preschool children prenatally exposed to opioid maintenance therapy (OMT) have an increased risk of neurodevelopmental impairments. We aimed to investigate long\u2010term motor and visual\u2010motor integration outcome in children aged 5\u201313\u2009Years, born to mothers in OMT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2018 to June 2021, 63 children prenatally exposed to OMT and 63 comparison children matched for age and gender, were examined at two Norwegian hospitals. Motor skills were assessed by the Movement\u2010ABC test and visual\u2010motor integration by the Beery VMI test. A motor function neurological assessment test was used to examine neuromotor soft signs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the OMT\u2010exposed group, 16% had motor impairment, 35% had motor problems and 19% had visual\u2010motor integration problems. Forty\u2010three percent of the exposed children had neuromotor soft signs. Strabismus had some influence on motor and visual\u2010motor outcomes but could not explain the group differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children prenatally exposed to opioid maintenance therapy have an increased risk of long\u2010term motor impairment and visual\u2010motor problems. In addition, they exhibit significantly more neuromotor soft signs, which may affect general well\u2010being, leisure activities and school performance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17175","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T11:55:38Z","timestamp":1709121338000},"page":"1331-1339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Children had increased risks of impaired motor and visual\u2010motor skills after prenatal exposure to opioid maintenance therapy"],"prefix":"10.1111","volume":"113","author":[{"given":"Anne Kathinka","family":"Aslaksen","sequence":"first","affiliation":[{"name":"Department of Pediatrics S\u00f8rlandet Hospital  Kristiansand Norway"},{"name":"Department of Pediatrics Haukeland University Hospital  Bergen Norway"},{"name":"Department of Clinical Medicine K1, Faculty of Medicine University of Bergen  Bergen 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