{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:24:57Z","timestamp":1778225097873,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>How maternal opioid maintenance treatment (OMT) affects children is under\u2010researched. This population\u2010based registry study investigated child growth and somatic health following intrauterine exposure to this treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children born between 1 March 2011 and 30 May 2021 to mothers who used buprenorphine, buprenorphine\u2010naloxone, or methadone throughout their pregnancies were followed for 2\u2009years at the Helsinki University Hospital, Finland. Appropriate statistical tests were used to compare the treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 67 neonates, 52% were male, 96% were born full\u2010term and 63% were treated for neonatal opioid withdrawal syndrome. Otherwise, the children were predominantly healthy, although relatively small: 22% were small for gestational age, the methadone group children being the smallest. Foetal exposure to maternal methadone treatment, illicit drugs, hepatitis C and smoking were associated with small for gestational age; the former two were also associated with later slower growth, especially head growth and weight gain (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). However, 29% were overweight at 2\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using child growth as the outcome, we found that buprenorphine\u2010naloxone and buprenorphine\u2010monotherapy had equal effects as forms of maternal OMT. Exposure to multiple risk factors may harm foetal and subsequent growth. We recommend long\u2010term follow\u2010up of children exposed to maternal OMT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17198","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T12:15:10Z","timestamp":1709900110000},"page":"1579-1591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intrauterine exposure to maternal opioid maintenance treatment and associated risk factors may impair child growth"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0373-9500","authenticated-orcid":false,"given":"Minna","family":"Kanervo","sequence":"first","affiliation":[{"name":"University of Helsinki Doctoral School  Helsinki Finland"},{"name":"Pediatric Research Center, Children's Hospital, Helsinki University Hospital University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liina","family":"Luoto","sequence":"additional","affiliation":[{"name":"Pediatric Research Center, Children's Hospital, Helsinki University Hospital University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarimari","family":"Tupola","sequence":"additional","affiliation":[{"name":"Pediatric Research Center, Children's Hospital, Helsinki University Hospital University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eeva","family":"Nikkola","sequence":"additional","affiliation":[{"name":"Pediatric Research Center, Children's Hospital, Helsinki University Hospital University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Kahila","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista","family":"Rantakari","sequence":"additional","affiliation":[{"name":"Pediatric Research Center, Children's Hospital, Helsinki University Hospital University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.12.018"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.7025"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12687"},{"key":"e_1_2_12_5_1","volume-title":"Guidelines for the identification and Management of Substance use and Substance use Disorders in 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