{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:23:07Z","timestamp":1791390187168,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008488","name":"Stiftelsen Alma och K. A. Snellman S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This nationwide study evaluated the clinical impact that an early thymectomy, during congenital heart defect (CHD) surgery, had on the health of children and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects were patients aged 1\u201315\u2009years who had undergone CHD surgery at the University Children's Hospital, Helsinki, where all CHD surgery in Finland is carried out, from 2006 to 2018. The parents or the cases and population\u2010based controls, matched for sex, age and hospital district, completed electronic questionnaires. We excluded those with low birth weights or a known immunodeficiency. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) were calculated for prespecified outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We received responses relating to 260\/450 (58%) cases and 1403\/4500 (31%) controls and excluded 73 cases with persistent cardiac or respiratory complaints after surgery. The CHD group reported more recurrent hospitalisations due to infections (aOR 6.3, 95% CI 3.0\u201313) than the controls and more pneumonia episodes (aOR 3.5, 95% CI 2.1\u20135.6), asthma (aOR 2.5, 95% CI 1.5\u20134.1) and wheezing (aOR 2.1, 95% CI 1.5\u20132.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hospitalisation due to infections, pneumonia, wheezing and asthma was more common in children after a thymectomy due to open\u2010heart surgery than population\u2010based controls, underlining the importance of immunological follow\u2010ups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17205","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T11:13:50Z","timestamp":1710846830000},"page":"1685-1693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pneumonia, wheezing and asthma were more common in children after thymectomy due to open\u2010heart surgery"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4771-9194","authenticated-orcid":false,"given":"Rea","family":"Rantanen","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Oulu University Hospital  Oulu Finland"},{"name":"Research Unit of Clinical Medicine and Medical Research Centre (MRC) Oulu University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna","family":"Honkila","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Oulu University Hospital  Oulu Finland"},{"name":"Research Unit of Clinical Medicine and Medical Research Centre (MRC) Oulu University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna\u2010Riikka","family":"K\u00e4m\u00e4","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Medicine and Medical Research Centre (MRC) Oulu University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tytti","family":"Pokka","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Oulu University Hospital  Oulu Finland"},{"name":"Research Unit of Clinical Medicine and Medical Research Centre (MRC) Oulu University of Oulu  Oulu Finland"},{"name":"Research Service Unit Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Pihkala","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, New Children's Hospital Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Rahkonen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, New Children's Hospital Helsinki University Hospital and University of Helsinki  Helsinki 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