{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:17:23Z","timestamp":1777501043863,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the prophylactic efficacy of ampicillin and clindamycin against vertical transmission of group B <jats:italic>Streptococcus<\/jats:italic> from mothers to their infants by evaluating the rates of group B <jats:italic>Streptococcus<\/jats:italic> colonisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively extracted data for mothers who delivered at Showa University Northern Yokohama Hospital between 1 October 2017 and 31 March 2021 and tested positive for antepartum group B <jats:italic>Streptococcus<\/jats:italic>, and their infants. The chi\u2010square test was used to compare the rates of group B <jats:italic>Streptococcus<\/jats:italic> colonisation, sepsis, and meningitis. We conducted a multivariate logistic regression analysis, including the time interval between membrane rupture and delivery, chorioamnionitis, and maternal intrapartum fever (\u226538.0\u00b0C).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred fifty\u2010nine mothers and their infants were eligible. Ampicillin and clindamycin were administered to 150 and 109 mothers, respectively. In the ampicillin and clindamycin groups, 12.0% (18\/150) and 37.6% (41\/109) infants were group B <jats:italic>Streptococcus<\/jats:italic> positive, respectively. The rate of group B <jats:italic>Streptococcus<\/jats:italic> colonisation among infants was significantly lower in the ampicillin group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multivariate regression analysis showed similar results (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). No sepsis or meningitis cases were observed in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prophylactic efficacy of clindamycin against the vertical transmission of group B <jats:italic>Streptococcus<\/jats:italic> is lower than that of ampicillin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17230","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T13:25:23Z","timestamp":1712323523000},"page":"1694-1700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intrapartum prophylactic efficacy of ampicillin versus clindamycin in preventing vertical transmission of group B <i>Streptococcus<\/i>"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-8034","authenticated-orcid":false,"given":"Gakuto","family":"Ujiie","sequence":"first","affiliation":[{"name":"Children Medical Center Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Murase","sequence":"additional","affiliation":[{"name":"Children Medical Center Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Asai","sequence":"additional","affiliation":[{"name":"Children Medical Center Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mio","family":"Igawa","sequence":"additional","affiliation":[{"name":"Children Medical Center Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotake","family":"Ichizuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0230-8933","authenticated-orcid":false,"given":"Hirokazu","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Children Medical Center Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-021-04396-y"},{"issue":"7","key":"e_1_2_11_3_1","first-page":"1","article-title":"Prevention of perinatal group B streptococcal disease: a public health perspective. 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