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All studies, except case reports, focusing on the antibiotic treatment of LRTI in children, with neurodisabilities were included. Outcomes included length of stay, intensive care admission and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies met the inclusion criteria (5115 patients). All the studies were of low quality. The shortest length of stay was with anaerobic and gram\u2010positive cover. Five studies used anaerobic, gram\u2010positive and gram\u2010negative cover (e.g., amoxicillin\u2010clavulanic acid), which was frequently adequate. In one large study, it was better than gram\u2010positive and gram\u2010negative cover alone (e.g. ceftriaxone). Those unresponsive or more unwell at presentation improved faster on <jats:italic>Pseudomonas aeruginosa<\/jats:italic> cover (e.g., piperacillin\u2010tazobactam).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this context, anaerobic, gram\u2010positive and gram\u2010negative cover is just as effective as <jats:italic>P. aeruginosa<\/jats:italic> cover, supporting empiric treatment with amoxicillin\u2010clavulanic acid. If there is a failure to improve, broadening to include <jats:italic>P. aeruginosa<\/jats:italic> could be considered. This is consistent with a consensus statement on the treatment of LRTI in children with neurodisability. An accepted definition for what constitutes LRTI in this cohort is required before designing prospective randomised trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17240","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T11:00:57Z","timestamp":1712660457000},"page":"1203-1208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antibiotics for the treatment of lower respiratory tract infections in children with neurodisability: Systematic review"],"prefix":"10.1111","volume":"113","author":[{"given":"Rachael M.","family":"Marpole","sequence":"first","affiliation":[{"name":"Department of Paediatrics University of Western Australia  Perth Western Australia Australia"},{"name":"Cerebral Palsy Alliance  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha C.","family":"Bowen","sequence":"additional","affiliation":[{"name":"Department 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