{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:57:58Z","timestamp":1790423878673,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To analyse the evidence of non\u2010invasive neurally adjusted ventilatory assist (NIV\u2010NAVA) in preterm neonates compared to nasal continuous positive airway pressure (nCPAP) or nasal intermittent positive pressure ventilation (NIPPV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic review and meta\u2010analysis of randomised controlled trials and included studies where NIV\u2010NAVA was analysed in preterm (&lt;37 gestational weeks) born neonates. Our main outcomes were the need for endotracheal intubation, the need for surfactant therapy, and reintubation rates. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of five studies were included. The endotracheal intubation rate was 25% in the NIV\u2010NAVA group and 26% in the nCPAP group (RR 0.91, CI: 0.56\u20131.48). The respective rates for surfactant therapy were 30% and 35% (RR 0.85, CI: 0.56\u20131.29). The reintubation rate in neonates previously invasively ventilated was 8% in the NIV\u2010NAVA group and 29% in the nCPAP\/NIPPV group (RR 0.29, 95%CI: 0.10\u20130.81). Evidence certainty was rated as low for all outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NIV\u2010NAVA as the primary respiratory support did not reduce the need for endotracheal intubation or surfactant therapy. NIV\u2010NAVA seemed to reduce the reintubation rate after extubation in pre\u2010term neonates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.17261","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T05:32:31Z","timestamp":1714800751000},"page":"2003-2010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Non\u2010invasive neurally adjusted ventilatory assist (\n                    <scp>NIV\u2010NAVA<\/scp>\n                    ) reduces extubation failures in preterm neonates\u2014A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-9610","authenticated-orcid":false,"given":"Ilari","family":"Kuitunen","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine and Department of Pediatrics University of Eastern Finland  Kuopio Finland"},{"name":"Department of Pediatrics Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0853-902X","authenticated-orcid":false,"given":"Kati","family":"R\u00e4s\u00e4nen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine and Department of Pediatrics University of Eastern Finland  Kuopio Finland"},{"name":"Department of Pediatrics Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528914"},{"key":"e_1_2_13_3_1","volume-title":"Evidence reviews for respiratory support: specialist neonatal respiratory care for babies born preterm: evidence review B","author":"National Guideline Alliance 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