{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T10:05:54Z","timestamp":1750759554785,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Bilateral nephrectomy is commonly performed in patients with congenital nephrotic syndrome of the Finnish type. The optimal timing of nephrectomy is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Growth, thromboembolic events, infections, transplant\u2010related complications and ability to eat were compared between infants with early (Group 1, <jats:italic>n<\/jats:italic>\u2009=\u200913) and late (Group 2, <jats:italic>n<\/jats:italic>\u2009=\u200910) nephrectomy. \u2018Early\u2019 was defined as nephrectomy at 7\u2010kg body weight followed by peritoneal dialysis and \u2018late\u2019 as nephrectomy at \u226510\u2009kg followed by 3\u20134\u2009weeks of haemodialysis and kidney transplantation. Patients were followed until the end of the first post\u2010transplant year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dialysis time was significantly longer in group 1 than in group 2. Late nephrectomy did not increase the risk for thromboembolic events or septicaemia but decreased tube feeding dependency (group 1 69% vs. group 2 20%, <jats:italic>p<\/jats:italic>\u2009=\u20090.019). Motor development at transplantation was considered normal in 80% of the infants with late nephrectomy compared to 31% in the early nephrectomy group (<jats:italic>p<\/jats:italic>\u2009=\u20090.019); however, the difference between the groups disappeared by the end of the follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Infants with late nephrectomy have comparative outcome but less feeding tube dependency and better motor development during the first post\u2010transplant months compared to infants with early nephrectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17294","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T11:55:07Z","timestamp":1716551707000},"page":"1957-1964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Late nephrectomy in infants with congenital nephrotic syndrome of the Finnish 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