{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:03:57Z","timestamp":1774343037628,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The effect of COVID\u201019 vaccine given during pregnancy on premature infants is unknown. This study aims to determine the association between maternal COVID\u201019 vaccine with postnatal outcome in premature infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a single\u2010centre retrospective case\u2013control study of infants born before 35\u2009weeks gestation to mothers who received SARS\u2010CoV\u20102 vaccine during pregnancy compared with infant born to non\u2010vaccinated mothers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 78 infants in each group were included. Infants in the vaccinated group had less respiratory distress syndrome (RDS) (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) and less need for respiratory support (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), and maternal vaccine had a protective effect on RDS [adjustable OR 0.38 (0.17\u20130.85)]. Vaccination during the first compared to the second trimester was associated with earlier gestational age (32.3\u2009\u00b1\u20092.1 vs. 33.3\u2009\u00b1\u20091.1\u2009weeks, <jats:italic>p<\/jats:italic>\u2009=\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrated that maternal SARS\u2010CoV\u20102 vaccine is not associated with postnatal adverse effect in premature infants and potentially has a protective effect on RDS. Earlier gestational age among the infants born to mothers who received COVID\u201019 vaccine during the first trimester did not translate to higher rate of postnatal complications. These findings might suggest that COVID\u201019 vaccine is safe in high\u2010risk pregnancies, but timing of administration should be considered. Further studies are needed to confirm our findings and the biological mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17329","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T04:58:21Z","timestamp":1719291501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of <scp>BNT162b2 SARS<\/scp>\u2010<scp>CoV<\/scp>\u20102 vaccination during pregnancy with postnatal outcomes in premature infants"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2404-7546","authenticated-orcid":false,"given":"Liran","family":"Tamir\u2010Hostovsky","sequence":"first","affiliation":[{"name":"Department of Neonatology, Edmond and Lily Safra Children's Hospital Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Faculty of Medical and Health Science Tel\u2010Aviv University  Tel\u2010Hashomer 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