{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:57:10Z","timestamp":1785225430097,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>There is no consensus on the best prophylaxis for supraventricular tachycardia (SVT) in infancy. We studied the efficacy and safety of sotalol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This retrospective study comprised infants diagnosed with SVT before 1\u2009year of age and treated with sotalol during 2002\u20132018 in Stockholm, Sweden. The patients' characteristics, comorbidities, sotalol dosages, QT intervals and outcomes were extracted from their medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 85 infants (65% boys) with a median age of eight (range 0\u2013288) days at the time of diagnosis, including 78 with re\u2010entry tachycardia. Sotalol was completely or partially successful in the 67\/75 patients who completed the treatment, as well as in four of the seven patients with other tachycardia mechanisms. The 48 infants with postnatal debut had significantly higher success rates than the 27 with foetal debut (96% vs. 78%, <jats:italic>p<\/jats:italic>\u2009=\u20090.04). Prolongation of corrected QT (QTc) intervals of \u2265450\u2009ms occurred in 16% of the total cohort and two patients with QTc intervals of \u2265500\u2009ms had their treatment changed. There were no cases of proarrhythmia after sotalol treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sotalol provided effective and safe prophylaxis for SVT during infancy. QTc prolongation rarely caused treatment discontinuation and there were no cases of proarrhythmia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17357","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T14:55:13Z","timestamp":1722264913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sotalol prophylaxis was efficient and safe for supraventricular tachycardia in early infancy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7693-2063","authenticated-orcid":false,"given":"Caroline","family":"Evertsson","sequence":"first","affiliation":[{"name":"Sachs' Children and Youth Hospital Stockholm South General Hospital (S\u00f6dersjukhuset)  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Eliasson","sequence":"additional","affiliation":[{"name":"Paediatric Cardiology Department, Astrid Lindgren Children's Hospital Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Pegelow","family":"Halvorsen","sequence":"additional","affiliation":[{"name":"Sachs' Children and Youth Hospital Stockholm South General Hospital (S\u00f6dersjukhuset)  Stockholm Sweden"},{"name":"Department of Clinical Science and Education, Stockholm South General Hospital (S\u00f6dersjukhuset) Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2015.04.001"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90858-v"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128072-200002030-00002"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90555-4"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1058-9813(00)00033-3"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-005-1126-x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/circep.112.972620"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900104"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1970.tb09893.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90500-x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00268-3"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1991.tb02816.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90024-7"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-021-02724-9"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90247-9"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90198-a"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248418810811"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2021.03.020"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.17357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T14:55:15Z","timestamp":1722264915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.17357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":18,"alternative-id":["10.1111\/apa.17357"],"URL":"https:\/\/doi.org\/10.1111\/apa.17357","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"assertion":[{"value":"2023-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"apa.17357"}}