{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:56:05Z","timestamp":1757541365476,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>In extremely low birth weight infants, fluid overload has been associated with bronchopulmonary dysplasia and death. Excessive weight loss may increase the risk of meconium obstruction and intestinal perforation. As these infants display oliguria followed by polyuria, we embarked on a diuresis\u2010led volume replacement strategy as of January 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010centre analysis presents data of infants &lt;1000\u2009g birth weight surviving for more than 3\u2009days admitted 2017\u20132019 (<jats:italic>n<\/jats:italic>\u2009=\u2009217, daily volume increase) versus 2020\u20132022 (<jats:italic>n<\/jats:italic>\u2009=\u20092022, diuresis\u2010led volume replacement).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The second cohort had lower gestational age (median [interquartile range]: 25<jats:sup>3<\/jats:sup>\/<jats:sub>7<\/jats:sub> [24<jats:sup>3<\/jats:sup>\/<jats:sub>7<\/jats:sub>\u201326<jats:sup>4<\/jats:sup>\/<jats:sub>7<\/jats:sub>] vs. 26<jats:sup>3<\/jats:sup>\/<jats:sub>7<\/jats:sub> [25<jats:sup>1<\/jats:sup>\/<jats:sub>7<\/jats:sub>\u201328<jats:sup>2<\/jats:sup>\/<jats:sub>7<\/jats:sub>] weeks), less antenatal steroids (58% vs. 69%), more indomethacin (66% vs. 47%) and higher initial diuresis (5.6 [4.9\u20136.8] vs. 4.8 [4.2\u20135.5] mL\/kg\/h) but did not differ by relative weight loss at Day 7 of life. Employing binary logistic regression with gestational age, antenatal steroids and indomethacin as covariates, the cohorts did not differ by rates of patent ductus arteriosus, abdominal surgery or severe retinopathy of prematurity, while there were significant declines in sepsis (from 32% to 19%), bronchopulmonary dysplasia (from 26% to 23%) and mortality (from 13% to 7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diuresis\u2010led volume replacement appears to be safe and maybe beneficial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17362","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T12:08:22Z","timestamp":1722514102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diuresis\u2010led volume replacement strategy in extremely low birth weight infants"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2545-0115","authenticated-orcid":false,"given":"Jonas Abbas","family":"Salloum","sequence":"first","affiliation":[{"name":"Department of Neonatology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Garten","sequence":"additional","affiliation":[{"name":"Department of Neonatology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-414X","authenticated-orcid":false,"given":"Christoph","family":"B\u00fchrer","sequence":"additional","affiliation":[{"name":"Department of Neonatology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin 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