{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:24:03Z","timestamp":1791080643451,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Associations between serum biomarkers S100 calcium\u2010binding protein B (S100B) and neuron\u2010specific enolase (NSE) in neonates with hypoxic\u2010ischaemic encephalopathy (HIE) offer contradicting data in regard to neurocognitive outcome. The aim of our study was to provide another dataset to answer this question if S100B or NSE correlates to outcome in neonatal HIE. In addition, we investigate whether amplitude\u2010integrated EEG (aEEG) or magnetic resonance imaging (MRI) also has predictive value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In neonates with HIE born in Vorarlberg, Austria, (<jats:italic>n<\/jats:italic>\u2009=\u200934) from 2012to 2020, NSE and S100B serum levels were measured on day one. aEEG was installed at admission and MRI performed within 7\u2009days. Surviving children (<jats:italic>n<\/jats:italic>\u2009=\u200927) were categorised as good or poor outcome by using an age\u2010appropriate neurocognitive test and a standardised neurological follow\u2010up. Positive and negative predictive values and receiver operating characteristic curves were calculated to evaluate the prognostic value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>S100B showed best positive and negative predictive value, 72.7% and 90.5%, respectively, and a significant area under the curve of 0.820. NSE showed a positive and a negative predictive value of 43.8% and 81.3% and an area under the curve of 0.757. Severely abnormal aEEG and abnormal MRI significantly correlated with outcome (<jats:italic>p<\/jats:italic>\u2009=\u20090.024 and 0.001 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>S100B and NSE on day one, severely abnormal aEEG and abnormal MRI show a significant correlation and good predictive value for neurocognitive outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17368","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T04:15:15Z","timestamp":1722485715000},"page":"2543-2549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Significant correlation between serum biomarkers and outcome in neonatal hypoxic\u2010ischaemic encephalopathy"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7035-4644","authenticated-orcid":false,"given":"Stefanie","family":"Gang","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Academic Teaching Hospital  Feldkirch Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Janko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Academic Teaching Hospital  Feldkirch Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Lamprecht","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Academic Teaching Hospital  Feldkirch Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Riedl","sequence":"additional","affiliation":[{"name":"Clinic for Psychiatry II, Department of Psychiatry, Psychotherapy, 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