{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T05:24:22Z","timestamp":1731475462648,"version":"3.28.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009448","name":"Universit\u00e0 degli Studi della Campania Luigi Vanvitelli","doi-asserted-by":"publisher","award":["D.R. n. 834\/2022","D.R. n. 639\/2023"],"award-info":[{"award-number":["D.R. n. 834\/2022","D.R. n. 639\/2023"]}],"id":[{"id":"10.13039\/501100009448","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the prevalence and determinants of failure to thrive (FTT) among patients with vesico\u2010ureteral reflux (VUR) and evaluating the effects of supplementation on growth in patients with urinary solute losses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively enrolled 1277 patients with VUR (mean age at diagnosis\u2009=\u20096.5\u2009months). Patients with FTT were screened for renal tubular function impairment (TFI). If fractional excretion of sodium (FENa) &gt;2% or blood bicarbonate &lt;20\u2009mmol\/L, supplementation was provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1277 patients, 56 (4.4%) had FTT. Of these, 42 (75%) presented extrarenal causes of FTT, 3 (5.4%) had chronic kidney disease (CKD), 9 (16.1%) had TFI, and 2 (3.5%) had CKD and TFI. FTT occurred in 8\/208 patients (3.8%) with and in 48\/1069 patients (4.5%) without (<jats:italic>p<\/jats:italic>\u2009=\u20090.68) recurrent urinary tract infections (UTIs). At multiple logistic regression, birthweight &lt;10th percentile, preterm birth, TFI, identified or suspected syndromes and other diseases were predictors of FTT. Eleven (19.6%) patients with FTT had TFI; five with increased FENa and\/or acidosis received supplementation and showed catch\u2010up growth. The remaining six patients exhibited spontaneous catch\u2010up growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FTT was found in &lt;5% of children with VUR. It was not determined by recurrent UTIs and was mainly associated with extrarenal causes. Supplementation with sodium and bicarbonates could be useful in selected cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17378","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T04:19:00Z","timestamp":1723090740000},"page":"2597-2603","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and determinants of failure to thrive in children with vesico\u2010ureteral reflux"],"prefix":"10.1111","volume":"113","author":[{"given":"Stefano","family":"Guarino","sequence":"first","affiliation":[{"name":"Department of Woman, Child and of General and Specialized Surgery Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Di\u00a0Sessa","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and of General and Specialized Surgery Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maeva","family":"De\u00a0Lucia","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and of General and Specialized Surgery Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Vitulano","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and of General and Specialized Surgery Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Rivetti","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and of General and Specialized Surgery Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giusy","family":"Capasso","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and of General and Specialized Surgery Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"La\u00a0Manna","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and of General and Specialized Surgery Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Polito","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and of General and Specialized Surgery Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Miraglia\u00a0del\u00a0Giudice","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and of General and Specialized Surgery Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Marzuillo","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and of General and Specialized Surgery Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"volume-title":"Nelson Textbook of Pediatrics","year":"2016","author":"Kliegman RM","key":"e_1_2_12_2_1"},{"volume-title":"Urinary Tract Infection in Children: Diagnosis, Treatment and Long\u2010Term Management","year":"2007","author":"National Institute for Health and Clinical Excellence","key":"e_1_2_12_3_1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.11.007"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-023-06173-9"},{"key":"e_1_2_12_6_1","first-page":"295","article-title":"Failure to thrive: a practical guide","volume":"94","author":"Homan GJ","year":"2016","journal-title":"Am Fam Physician"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3928\/00904481-20160114-01"},{"key":"e_1_2_12_8_1","unstructured":"Faltering growth\u2014Symptoms diagnosis and treatment | BMJ Best Practice. 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