{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:11:02Z","timestamp":1788390662296,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Opioids might be harmful to the developing brain and dosing accuracy is important. We aimed at investigating fentanyl effects on cortical activity in infants using computational re\u2010analysis of bedside recorded EEG signals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen infants born at median 26.4 gestational weeks (range 23.3\u201334.1), with a birth weight 740 grams (530\u20131420) and postnatal age 7\u2009days (5\u201311) received fentanyl 0.5 or 2\u2009\u03bcg\/kg intravenously before a skin\u2010breaking procedure or tracheal intubation, respectively. Cortical activity was continuously recorded using amplitude\u2010integrated electroencephalography (aEEG). \u00a0Analyses using three computational EEG features representing cortical synchrony and signal power, were conducted five minutes pre\u2010 and 10 minutes post the drug administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Visual assessment of trends displayed from the EEG metrics did not indicate systematic changes. However, the magnitude of the changes in the parietal and right hemisphere signals after the dose was significantly correlated (<jats:italic>\u03c1<\/jats:italic>\u2009&lt;\u2009\u22120.5, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) to the EEG amplitude and frequency power level before drug administration. This effect started after 3\u20134\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fentanyl, even in small doses, may affect cortical activity in the preterm brain. The effect is robustly related to the state of cortical activity prior to drug treatment, which must be taken into account when analysing the effects of sedative drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17411","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T13:27:47Z","timestamp":1726061267000},"page":"109-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Depression of cortical neuronal activity after a low\u2010dose fentanyl in preterm infants"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0396-8597","authenticated-orcid":false,"given":"Sofie","family":"Nilsson","sequence":"first","affiliation":[{"name":"Pediatrics, Department of Clinical Sciences Lund Lund University, Skane University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Tokariev","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, BABA Center, New Children's Hospital Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Vehvil\u00e4inen","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, BABA Center, New Children's Hospital Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1355-5633","authenticated-orcid":false,"given":"Vineta","family":"Fellman","sequence":"additional","affiliation":[{"name":"Pediatrics, Department of Clinical Sciences Lund Lund University, Skane University Hospital  Lund Sweden"},{"name":"Folkh\u00e4lsan Research Center and Children's Hospital University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9771-7061","authenticated-orcid":false,"given":"Sampsa","family":"Vanhatalo","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, BABA Center, New Children's Hospital Helsinki University Hospital and University of Helsinki  Helsinki Finland"},{"name":"Department of Physiology, Clinicum University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6346-8899","authenticated-orcid":false,"given":"Elisabeth","family":"Norman","sequence":"additional","affiliation":[{"name":"Pediatrics, Department of Clinical Sciences Lund Lund University, Skane University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.757"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2019.04.005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311066"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2012.02677.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0744-6"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2021.101273"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.803708"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2019.05.008"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2018.02.003"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51043"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64211-0"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/s23010444"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2014.06.002"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14744"},{"key":"e_1_2_12_16_1","volume-title":"Effects of Fentanyl on the Cortical Activity of Neonates","author":"Vehvilainen T","year":"2019"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.12.017"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.02.087"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.05.019"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2006.07.008"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.11.008"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.1.e61"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.062745"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.02.017"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.153"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2017.60"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13180"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-55231-6_18"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00065"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00117"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0160-3"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.17411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:17:14Z","timestamp":1737613034000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.17411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/apa.17411"],"URL":"https:\/\/doi.org\/10.1111\/apa.17411","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]},"assertion":[{"value":"2024-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}