{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:24:15Z","timestamp":1753878255562,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Concerns exist regarding potential adverse neurodevelopmental outcomes associated with paracetamol exposure during pregnancy and early infancy. This review evaluates the evidence for the impact of paracetamol use for patent ductus arteriosus (PDA) treatment on neurodevelopmental outcomes in preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was performed via Medline, Ovid Embase and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases. The search details are below: (\u2018Infant, Newborn\u2019 [MeSH] OR \u2018neonate*\u2019 [Title\/Abstract]) AND (\u2018Paracetamol\u2019 [MeSH] OR \u2018Acetaminophen\u2019 [Title\/Abstract]) AND (\u2018Ductus Arteriosus, Patent\/drug therapy\u2019 [MeSH] OR \u2018patent ductus arteriosus\u2019 [Title\/Abstract]) AND (\u2018Neurodevelopmental Disorders\u2019 [MeSH] OR \u2018neurodevelopment*\u2019 [Title\/Abstract] OR \u2018Child Development\u2019 [MeSH] OR \u2018Developmental Disabilities\u2019 [MeSH]). All studies were critically appraised and synthesised.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven studies reported neurodevelopmental outcomes after paracetamol use for PDA treatment in preterm infants &lt;32\u2009weeks gestation. The studies varied in dosage, route, and duration of paracetamol administration and in the methods used to assess neurodevelopmental outcomes. None of the studies revealed different outcomes between paracetamol\u2010exposed preterm infants and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current low\u2010to\u2010moderate quality evidence suggests no association between paracetamol used for PDA treatment and adverse neurodevelopmental outcomes in preterm infants. Future well\u2010powered studies with standardised neurodevelopmental assessments are warranted to strengthen the current evidence base.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17415","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T11:15:53Z","timestamp":1725362153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurodevelopmental outcomes following paracetamol use for treatment of patent ductus arteriosus: A review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-4945","authenticated-orcid":false,"given":"Adam","family":"Pearce","sequence":"first","affiliation":[{"name":"Department of Neonatology University Hospitals Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis","family":"Saunders","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics Birmingham Women's and Children's NHS Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Dunlop","sequence":"additional","affiliation":[{"name":"CEBIS, University Hospitals Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4033-784X","authenticated-orcid":false,"given":"Asad","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Neonatology Birmingham Heartlands Hospital and KIDSNTS Transport Team  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2020-320207"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/BCP.15291"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw192"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12582"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12632"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-3840"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.1775"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kft329"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0359"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010061.pub5"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15970"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16806"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-023-02649-4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.1875444"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cch.12997"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-021-01194-4"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14614"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1601564"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2305582"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207418"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j\/jpeds.2021.02.026"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.17415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T11:15:55Z","timestamp":1725362155000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.17415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":21,"alternative-id":["10.1111\/apa.17415"],"URL":"https:\/\/doi.org\/10.1111\/apa.17415","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"type":"print","value":"0803-5253"},{"type":"electronic","value":"1651-2227"}],"subject":[],"published":{"date-parts":[[2024,9,3]]},"assertion":[{"value":"2024-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"apa.17415"}}