{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T05:09:50Z","timestamp":1737695390853,"version":"3.33.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Dexmedetomidine is commonly used in hospitals for sedation during procedurals. It has been considered safe even though studies have shown that it may cause bradycardia and hypotension. The aim of this study was to map the current evidence regarding potential risks of sedation of children with dexmedetomidine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two database searches were conducted to gather all articles published through 30 January 2024 that matched the inclusion criteria. PubMed and Embase were chosen for the initial search. Search terms were chosen to create a broad systematic search that would include articles reporting adverse events during procedural sedation on children. From the included articles, data on type of sedation, administration, patient characteristics, endpoints and number of adverse events were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the initial search, 357 individual papers were screened and 41 papers were included. The most common adverse event reported was bradycardia. In almost 40% of the articles that measured oxygen saturation, one or more incidents of desaturation occurred. 27% reported that interventions to prevent further harm were preformed, most of the interventions were to improve oxygenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a need for further investigation regarding adverse events, especially respiratory adverse events during sedation with dexmedetomidine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17435","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T06:23:14Z","timestamp":1728109394000},"page":"24-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scoping review finds insufficient evidence on potential risks of procedural sedation with dexmedetomidine in children"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5692-5065","authenticated-orcid":false,"given":"Anna","family":"B\u00e5telsson","sequence":"first","affiliation":[{"name":"Perioperative Medicine and Intensive Care Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Lannsj\u00f6","sequence":"additional","affiliation":[{"name":"Anesthesiology V\u00e4stmanland Hospital V\u00e4ster\u00e5s  V\u00e4ster\u00e5s Sweden"},{"name":"Department of Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urban","family":"Fl\u00e4ring","sequence":"additional","affiliation":[{"name":"Department of Pediatric Perioperative Medicine and Intensive Care Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Physiology and Pharmacology Karolinska Institute  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav","family":"Rooyackers","sequence":"additional","affiliation":[{"name":"Perioperative Medicine and Intensive Care Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Clinical Science, Technology and Intervention Karolinska Instititet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68230-5"},{"key":"e_1_2_11_3_1","first-page":"1231","volume-title":"Is Propofol Safe for Procedural Sedation in Children? A Prospective Evaluation of Propofol versus Ketamine in Pediatric Critical Care*","author":"Vardi A","year":"2002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13844"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68230-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200008000-00016"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2018-0162"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001451"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02748.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-020-00978-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000602"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13120"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25827"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12851"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12569"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.14423\/SMJ.0000000000000160"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.011"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.6134"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2008.03.004"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13509"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13293"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.5045"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.148318"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-016-0617-y"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13121232"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12907"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02468.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13514"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/397372"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.11580"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-018-3582-1"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.14290"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584683"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13693"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13235"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012140"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/joacp.JOACP_20_18"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.egja.2013.09.006"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073814549582"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12287"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.egja.2012.08.002"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-015-0145-1"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2013.12.006"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2022.01.005"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2023.10.006"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-022-04794-0"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-021-03178-x"},{"key":"e_1_2_11_50_1","doi-asserted-by":"crossref","unstructured":"V Prospective_evaluation_of_dexmedetomidine_for Non\u2010invasive procedural sedation in children.5. Pediatr Crit Care Med.2005;6(4):435\u2010439.","DOI":"10.1097\/01.PCC.0000163680.50087.93"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-6723.2010.01298.x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2013.10.012"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001236"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.17435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:17:00Z","timestamp":1737613020000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.17435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,4]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/apa.17435"],"URL":"https:\/\/doi.org\/10.1111\/apa.17435","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"type":"print","value":"0803-5253"},{"type":"electronic","value":"1651-2227"}],"subject":[],"published":{"date-parts":[[2024,10,4]]},"assertion":[{"value":"2024-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}