{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:20:16Z","timestamp":1790508016897,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the duration of relapsing childhood idiopathic nephrotic syndrome (INS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this population\u2010based study, we retrospectively analysed the computerised database of Israel's largest health maintenance organisation. Children (age 2\u201310\u2009years) with a new INS diagnosis and a corticosteroid (CS) prescription between 2000 and 2010 were included. NS category was determined, according to CS and\/or steroid\u2010sparing agents (SSA) purchases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 1\u2009669\u2009977 eligible children, 608 fulfilled inclusion criteria. Patients in the fourth quartile of purchases (<jats:italic>n<\/jats:italic>\u2009=\u2009132) had an older age at last relapse (17.9\u2009\u00b1\u20096.3 vs. 11.3\u2009\u00b1\u20095.9\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and more SSA use (78.8% vs. 20%, p\u2009&lt;\u20090.001) compared to the remaining three quartiles. A single episode occurred in 84 patients. Of the remaining 524 patients (males 66%, diagnosis age: 4.8\u2009\u00b1\u20092.2\u2009years, SSA prescribed: 35%) who were followed for 15.5\u2009\u00b1\u20095.1\u2009years, 113 (21.6%) had a continuing disease at an age of 19.3\u2009\u00b1\u20096.3\u2009years. The leftover 411 entered long\u2010lasting treatment\u2010free remission at age 11.2\u2009\u00b1\u20095.7\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this multicentre study, we identified INS disease course by medication delivery. NS long\u2010standing remission occurs at age 11.2\u2009\u00b1\u20095.7\u2009years in most cases. However, the disease continues into adulthood in a fifth of the relapsing patients, implicating the need for proper transition to adult care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17436","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T07:39:42Z","timestamp":1728286782000},"page":"364-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Resolution versus persistence of childhood idiopathic nephrotic syndrome\u2014A population\u2010based study"],"prefix":"10.1111","volume":"114","author":[{"given":"Evgenia","family":"Gurevich","sequence":"first","affiliation":[{"name":"Southern District Clalit Health Services Pediatric Nephrology  Beer Sheva Israel"},{"name":"Barzilay University Medical Center  Ashkelon Israel"},{"name":"Ben Gurion University  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odeyah","family":"Abeles","sequence":"additional","affiliation":[{"name":"Soroka Clinical Research Center  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6347-7891","authenticated-orcid":false,"given":"Daniel","family":"Landau","sequence":"additional","affiliation":[{"name":"Department of Nephrology Schneider Children's Medical Center of Israel  Petah Tikva Israel"},{"name":"Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"155","volume-title":"Clinical Pediatric Nephrology","author":"Valentini RP","year":"2007"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91387-X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2003.50116"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5414\/cn108044"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.03.050"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2019.12.015"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-019-01696-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.05.017"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac166"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad726"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3509-z"},{"issue":"5","key":"e_1_2_11_13_1","first-page":"1023","article-title":"Predictors of persistent disease activity in childhood minimal\u2010change nephrotic syndrome","volume":"1","author":"Chwat J","year":"2014","journal-title":"Austin J Nephrol Hypertens"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.2.351"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012070646"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0800459"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0019"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.398"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.00274576"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(89)91266-x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.09.003"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2020.104092"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.17436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T05:32:21Z","timestamp":1756445541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.17436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/apa.17436"],"URL":"https:\/\/doi.org\/10.1111\/apa.17436","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,7]]},"assertion":[{"value":"2024-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}