{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T06:10:05Z","timestamp":1756447805286,"version":"3.44.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Cerebral venous thrombosis (CVT) is a rare complication of ear, nose and throat (ENT) infections. Although recent guidelines recommend the systematic use of anti\u2010coagulation therapy (ACT) in the treatment of these CVT, literature data are scarce. The present study's objective was to determine the value of ACT in achieving recanalisation after thrombosis and its effect on patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All paediatric patients with CVT and a concomitant ENT infection who attended Lille University Hospital (Lille, France) between January 2012 and December 2021 were retrospectively included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 43 children (63% boys), with a mean age of 4\u2009years. The most frequent infection was mastoiditis (54%). ACT was initiated in 23 patients (53%), one of whom had an intracranial haemorrhage. Partial or full recanalisation was observed in 33 (80%) of the 41 survivors. In patients with no neurological signs and symptoms on admission and in patients with mastoiditis\u2010related CVT, the clinical and radiological outcomes were favourable and did not differ according to the administration of ACT. Likewise, ACT did not appear to influence the recanalisation rate or sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ACT was not necessary for all patients with mastoiditis\u2010related CVT and those with no neurological signs and symptoms on admission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17439","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:13:57Z","timestamp":1727914437000},"page":"378-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A 10\u2010year cross\u2010sectional study showed that anti\u2010coagulation therapy was not always of value when treating paediatric cases with septic cerebral venous thrombosis"],"prefix":"10.1111","volume":"114","author":[{"given":"Juliette","family":"Eloy","sequence":"first","affiliation":[{"name":"CHU Lille Paediatric Emergency Unit and Infectious Diseases  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Hochart","sequence":"additional","affiliation":[{"name":"CHU Lille Department of Haemostasis and Transfusion  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Soto\u2010Ares","sequence":"additional","affiliation":[{"name":"CHU Lille Department of Neuroradiology  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Lagree","sequence":"additional","affiliation":[{"name":"CHU Lille Paediatric Emergency Unit and Infectious Diseases  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9gory","family":"Kuchcinski","sequence":"additional","affiliation":[{"name":"CHU Lille Department of Neuroradiology  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lodie\u2010Anne","family":"Karnoub","sequence":"additional","affiliation":[{"name":"CHU Lille Department of Paediatric Neurosurgery  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alix","family":"Maltezeanu","sequence":"additional","affiliation":[{"name":"CHU Lille Department of Paediatric Otolaryngology\u2010Head and Neck Surgery  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Leteurtre","sequence":"additional","affiliation":[{"name":"CHU Lille, Paediatric Intensive Care Unit Jeanne de Flandre Hospital  Lille France"},{"name":"Univ. Lille ULR 2694 \u2013 METRICS: Assessment of Health Technologies and Medical Practices  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Dubos","sequence":"additional","affiliation":[{"name":"CHU Lille Paediatric Emergency Unit and Infectious Diseases  Lille France"},{"name":"Univ. Lille ULR 2694 \u2013 METRICS: Assessment of Health Technologies and Medical Practices  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_11_2_1","DOI":"10.1093\/infdis\/160.1.83"},{"doi-asserted-by":"publisher","key":"e_1_2_11_3_1","DOI":"10.1136\/archdischild-2014-306382"},{"doi-asserted-by":"publisher","key":"e_1_2_11_4_1","DOI":"10.1056\/NEJM200108093450604"},{"doi-asserted-by":"publisher","key":"e_1_2_11_5_1","DOI":"10.1161\/CIRCULATIONAHA.111.067835"},{"doi-asserted-by":"publisher","key":"e_1_2_11_6_1","DOI":"10.1016\/j.ijporl.2015.10.059"},{"doi-asserted-by":"publisher","key":"e_1_2_11_7_1","DOI":"10.1111\/coa.13478"},{"doi-asserted-by":"publisher","key":"e_1_2_11_8_1","DOI":"10.14639\/0392-100X-N1835"},{"doi-asserted-by":"publisher","key":"e_1_2_11_9_1","DOI":"10.1186\/s13052-020-00882-9"},{"doi-asserted-by":"publisher","key":"e_1_2_11_10_1","DOI":"10.1016\/j.ijporl.2016.06.013"},{"doi-asserted-by":"publisher","key":"e_1_2_11_11_1","DOI":"10.1111\/coa.12504"},{"doi-asserted-by":"publisher","key":"e_1_2_11_12_1","DOI":"10.1016\/j.ejpn.2008.12.004"},{"doi-asserted-by":"publisher","key":"e_1_2_11_13_1","DOI":"10.1080\/00016480802399721"},{"doi-asserted-by":"publisher","key":"e_1_2_11_14_1","DOI":"10.1016\/S1164-6756(01)00131-1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_15_1","DOI":"10.1016\/j.crad.2019.12.009"},{"doi-asserted-by":"publisher","key":"e_1_2_11_16_1","DOI":"10.23750\/abm.v91i1-S.9259"},{"doi-asserted-by":"publisher","key":"e_1_2_11_17_1","DOI":"10.1016\/j.medmal.2019.03.009"},{"doi-asserted-by":"publisher","key":"e_1_2_11_18_1","DOI":"10.1002\/14651858.CD006089.pub5"},{"doi-asserted-by":"publisher","key":"e_1_2_11_19_1","DOI":"10.1016\/j.emc.2021.04.012"},{"doi-asserted-by":"publisher","key":"e_1_2_11_20_1","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105845"},{"unstructured":"Medistica.pvalue.io a GUI of R statistical software for scientific medical publications. pvalue.Io.2019.https:\/\/www.pvalue.io. Accessed March 8 2024.","key":"e_1_2_11_21_1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_22_1","DOI":"10.1161\/STR.0000000000000183"},{"doi-asserted-by":"publisher","key":"e_1_2_11_23_1","DOI":"10.1016\/S2352-3026(19)30219-4"},{"doi-asserted-by":"publisher","key":"e_1_2_11_24_1","DOI":"10.23750\/abm.v94i2.13839"},{"doi-asserted-by":"publisher","key":"e_1_2_11_25_1","DOI":"10.1097\/INF.0000000000000920"},{"doi-asserted-by":"publisher","key":"e_1_2_11_26_1","DOI":"10.1016\/j.ijporl.2018.07.050"},{"doi-asserted-by":"publisher","key":"e_1_2_11_27_1","DOI":"10.1111\/dmcn.15331"},{"doi-asserted-by":"publisher","key":"e_1_2_11_28_1","DOI":"10.1016\/j.ijporl.2011.03.024"},{"doi-asserted-by":"publisher","key":"e_1_2_11_29_1","DOI":"10.3171\/2023.2.PEDS2319"},{"unstructured":"Protocole National de Diagnostic et de Soins (PNDS).Thrombose veineuse c\u00e9r\u00e9brale de l'enfant.2021.https:\/\/www.has\u2010sante.fr\/upload\/docs\/application\/pdf\/2021\u201010\/texte_pnds_tvc.pdf. Accessed July 13 2023.","key":"e_1_2_11_30_1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_31_1","DOI":"10.1111\/j.1365-2141.2010.08543.x"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.17439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T05:32:13Z","timestamp":1756445533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.17439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/apa.17439"],"URL":"https:\/\/doi.org\/10.1111\/apa.17439","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"type":"print","value":"0803-5253"},{"type":"electronic","value":"1651-2227"}],"subject":[],"published":{"date-parts":[[2024,10,2]]},"assertion":[{"value":"2024-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}