{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:48:09Z","timestamp":1790192889836,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this review was to summarise the current knowledge on host\u2010related factors that contribute to the development and severity of staphylococcal scalded skin syndrome (SSSS) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive assessment and analysis of the existing literature on SSSS clinical features, pathogenesis and susceptibility factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SSSS is a blistering skin disease caused by circulating exfoliative toxins (ETs) of <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:italic>S<\/jats:italic>. <jats:italic>aureus<\/jats:italic>), almost exclusively affecting infants, young children and immunocompromised individuals. ETs possess serine protease activity and target desmoglein\u20101 (Dsg\u20101) in the superficial epidermis. While the role of <jats:italic>S. aureus<\/jats:italic> ETs and site of action are well\u2010described, other host factors such as impaired immune responses to ETs, poor renal clearance and genetic factors are crucial for the onset of and\/or the severity of SSSS in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The fate of desmosomal fractions after cleavage by ETs, as well as the role of dermal inflammatory cell infiltrates remain to be elucidated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17462","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T06:28:47Z","timestamp":1729060127000},"page":"241-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Understanding host's response to staphylococcal scalded 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