{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:51:41Z","timestamp":1791449501421,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009128","name":"Research for Patient Benefit Programme","doi-asserted-by":"publisher","award":["NIHR203034"],"award-info":[{"award-number":["NIHR203034"]}],"id":[{"id":"10.13039\/501100009128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>CoolCuddle, enabling parents to cuddle their babies with neonatal encephalopathy (NE) during therapeutic hypothermia and intensive care (TH), was developed in research settings. To determine the impact of implementing CoolCuddle in usual care in six diverse neonatal intensive care units on the cooling process and intensive care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This vital sign cohort study embedded within the CoolCuddle implementation study enrolled 36 infants receiving TH for NE. Nurses received training on CoolCuddle and a standard operating procedure using an instruction video. After consenting, parents experienced up to 2\u2009h of CoolCuddle with 30\u2009min of pre\u2010 and post\u2010cuddle observation. We used multilevel, clustered linear modelling to assess the physiological stability in temperature, cardio\u2010respiratory and neurophysiology across the CoolCuddle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 60 CoolCuddles over 93.12\u2009h, respiratory parameters, heart rate or neurological function did not vary between the epochs (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). During cuddle, sleep\u2013wake cycling on amplitude\u2010integrated EEG increased (<jats:italic>p<\/jats:italic>\u2009=\u20090.008) and there was weak evidence of lower pain scores (<jats:italic>p<\/jats:italic>\u2009=\u20090.08). No adverse effects were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Implementing CoolCuddle with support in usual practice maintained physiological stability and did not significantly affect the cooling process or intensive care, and may improve infant comfort. Ongoing monitoring of adverse effects when implementing CoolCuddle is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17466","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T13:23:47Z","timestamp":1729862627000},"page":"546-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cooling and physiology during parent cuddling infants with neonatal encephalopathy in usual care: CoolCuddle\u20102 study"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3380-047X","authenticated-orcid":false,"given":"Ela","family":"Chakkarapani","sequence":"first","affiliation":[{"name":"Centre for Academic Child Health, Bristol Medical School University of Bristol  Bristol UK"},{"name":"St Michael's Hospital University Hospitals Bristol and Weston NHS Foundation Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Ingram","sequence":"additional","affiliation":[{"name":"Centre for Academic Child Health, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Stocks","sequence":"additional","affiliation":[{"name":"St Michael's Hospital University Hospitals Bristol and Weston NHS Foundation Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Beasant","sequence":"additional","affiliation":[{"name":"Centre for Academic Child Health, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Odd","sequence":"additional","affiliation":[{"name":"School of Medicine Cardiff University and University Hospital of Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CoolCuddle\u20102 study research team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Therapeutic Hypothermia with Intracorporeal Temperature Monitoring for Hypoxic Perinatal Brain Injury. 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