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Cognitive development was evaluated in 22 adults (7 males and 15 females) and 20 children (8 males and 12 females) using age\u2010specific Wechsler Intelligence Scales. Full\u2010scale IQ (FSIQ) and the four indices were compared to standardisation samples. Simple linear regression was used to test whether treatment\u2010related variables predicted FSIQ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FSIQ and its four indices differed significantly from the standardisation sample in adults with congenital hypothyroidism (FSIQ 87.64, SD 13.70, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but not in children (FSIQ 97.90, SD 15.12). Adults had received a lower initial levothyroxine dose than children (8.1\u2009mg\/kg, 95% CI 7.2\u20139.0 vs. 10.2\u2009mg\/kg 9.7\u201310.7, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and their treatment was initiated later (4.8\u2009days, 95% CI 4.0\u20135.6 vs. 3.6\u2009days, 2.9\u20134.2, <jats:italic>p<\/jats:italic>\u2009=\u20090.018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adults with congenital hypothyroidism had a significantly lower FSIQ compared to the population standard, while children's FSIQ did not differ. Our findings suggest that a higher initial levothyroxine dose together with very early treatment start may lead to better cognitive outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17479","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T06:39:32Z","timestamp":1730529572000},"page":"594-602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Higher initial levothyroxine doses and very early treatment start may lead to better cognitive outcomes in children with congenital hypothyroidism"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-9907","authenticated-orcid":false,"given":"Emmi","family":"Danner","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Eastern Finland and Kuopio University Hospital  Kuopio 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