{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:43:45Z","timestamp":1789055025379,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This retrospective study aimed to assess the efficacy of prophylactic antibiotics in preventing ascending cholangitis following Kasai portoenterostomy (KPE). Data from 72 patients treated across four tertiary centres in Israel from 2008 to 2018 were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and laboratory data were collected from biliary atresia (BA) diagnosis until liver transplantation (LT) or study completion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age at KPE was 58.5\u2009days. Successful KPE was achieved in 23 (32%) patients. Ascending cholangitis occurred in 6\/23 (26%) successful KPE cases and 15\/45 (33%) unsuccessful cases. Primary antibiotic prophylaxis (49% of patients) was associated with earlier onset of cholangitis (median 77 vs 239\u2009days, <jats:italic>p<\/jats:italic>\u2009=\u20090.016). During follow\u2010up, 39% underwent LT, with a 5\u2010year survival with native liver (SNL) of 54%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prophylactic antibiotics did not reduce cholangitis rates post\u2010KPE in our cohort. Further research is essential to optimise management strategies for infants with BA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17493","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T01:14:17Z","timestamp":1731374057000},"page":"654-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary antibiotic prophylaxis in biliary atresia did not demonstrate decreased infection rate: Multi\u2010centre retrospective study"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4600-3791","authenticated-orcid":false,"given":"Yael","family":"Brody","sequence":"first","affiliation":[{"name":"Schneider Children's Medical Center of Israel  Petach\u2010Tiqva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mordechai","family":"Slae","sequence":"additional","affiliation":[{"name":"The Center for Pediatric Liver Diseases Hadassah University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2231-4209","authenticated-orcid":false,"given":"Achiya Z.","family":"Amir","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Liver and Nutrition Unit Dana Dwek Children's Hospital  Tel\u2010Aviv Israel"},{"name":"Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Mozer\u2010Glassberg","sequence":"additional","affiliation":[{"name":"Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center of Israel  Petach\u2010Tiqva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Bar\u2010Lev","sequence":"additional","affiliation":[{"name":"Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center of Israel  Petach\u2010Tiqva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Shteyer","sequence":"additional","affiliation":[{"name":"The Juliet Keidan Institute of Pediatric Gastroenterology Shaare Zedek Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orith","family":"Waisbourd\u2010Zinman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center of Israel  Petach\u2010Tiqva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1038479"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.01.040"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60946-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1949"},{"issue":"3","key":"e_1_2_11_6_1","first-page":"131","article-title":"Canadian biliary atresia registry. The Canadian biliary atresia registry: improving the care of Canadian infants with biliary atresia","volume":"21","author":"Butler AE","year":"2016","journal-title":"Paediatrics & Child Health"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02355-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20547"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-021-04916-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002243"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-021-05047-1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21219"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.924506"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-317787"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211012596"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp-21-309"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2018.10.060"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002446"},{"key":"e_1_2_11_19_1","first-page":"1680","article-title":"Five\u2010year native liver survival analysis in biliary atresia from a single large Chinese center: the death\/liver transplantation hazard change and the importance of rapid","volume":"54","author":"Wang Z","year":"2019","journal-title":"The Journal of Pediatrics"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.04.013"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030494"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11030387"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922815594760"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002837"},{"issue":"1","key":"e_1_2_11_25_1","first-page":"S354","article-title":"579. Prophylactic antibiotics did not decrease recurrent cholangitis in patients with biliary atresia after kasai portoenterostomy. Open forum","volume":"7","author":"Tarro TM","year":"2020","journal-title":"Infectious Diseases"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-006-1156-7"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.989"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-017-0555-z"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.08.407"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.17493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T03:03:54Z","timestamp":1739588634000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.17493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/apa.17493"],"URL":"https:\/\/doi.org\/10.1111\/apa.17493","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"2024-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}