{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:00:05Z","timestamp":1785438005360,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>A study reported that therapeutic hypothermia (TH) did not reduce the combined prognosis of mortality and disability at 18\u2009months, in low\u2010 and middle\u2010income countries for patients with hypoxic ischaemic encephalopathy (HIE) who received TH, suggesting its no implementation in these regions.<\/jats:p>\n                    <jats:p>We described characteristics, mortality, and neurological response before and after the use of TH in newborns with HIE within the EpicLatino Neonatal Network (ENN) and described the population of infants with HIE treated and not treated with TH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from 2015 to 2022 for patients with HIE. Mortality rates and Sarnat scores were compared before and after TH. The Wilcoxon Signed\u2010Rank Test was used for comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this observational study 518 neonates of our total population of 26\u2009970, had HIE (1.92%) of whom 150 underwent TH. Ten out of 21 neonatal intensive care units (NICUs) provided TH. The Wilcoxon Signed Rank Test for 138 cases with complete data showed a significant difference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings support the benefits of TH in HIE within this cohort. TH should not be withheld solely due to the economic status of the country. A strict patient selection and TH protocol are essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.17504","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T23:33:38Z","timestamp":1731972818000},"page":"922-928","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic hypothermia success for hypoxic\u2010ischaemic encephalopathy in Latin America: Eight\u2010year experience in\n                    <scp>EpicLatino<\/scp>\n                    Neonatal Network"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-0385","authenticated-orcid":false,"given":"Carlos","family":"Fajardo","sequence":"first","affiliation":[{"name":"Pediatrics University of Calgary  Calgary Alberta Canada"},{"name":"EpicLatino Neonatal Network  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Belzu","sequence":"additional","affiliation":[{"name":"EpicLatino Neonatal Network  Calgary Alberta Canada"},{"name":"Cl\u00ednica Las Americas  Santa Cr\u00faz Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Bernal Benitez","sequence":"additional","affiliation":[{"name":"EpicLatino Neonatal Network  Calgary Alberta Canada"},{"name":"Hospital Miguel Hidalgo  Aguas Calientes Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5403-3268","authenticated-orcid":false,"given":"\u00c1ngela","family":"Hoyos","sequence":"additional","affiliation":[{"name":"EpicLatino Neonatal Network  Calgary Alberta Canada"},{"name":"Universidad del Bosque  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Hern\u00e1ndez Pati\u00f1o","sequence":"additional","affiliation":[{"name":"EpicLatino Neonatal Network  Calgary Alberta Canada"},{"name":"Hospital Miguel Hidalgo  Aguas Calientes Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Monterrosa","sequence":"additional","affiliation":[{"name":"EpicLatino Neonatal Network  Calgary Alberta Canada"},{"name":"DalHousie University  Saint John New Brunswick Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Villegas","sequence":"additional","affiliation":[{"name":"EpicLatino Neonatal Network  Calgary Alberta Canada"},{"name":"Hospital Central  San Luis Potos\u00ed Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"EpicLatino Neonatal Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60560-1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40748-018-0074-4"},{"key":"e_1_2_12_4_1","unstructured":"WHO World Health Statistics presents the most recent health statistics for WHO's Member States. UN data | record view | Neonatal mortality rate (per 1000 live births) Taken from the UN retrieval system on March 21 2024."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-11-07250.1995"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199806000-00005"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200203000-00015"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199505000-00019"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2895"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199404000-00010"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199707000-00004"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119153"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17946-X"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003311.pub3"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(21)00264-3"},{"key":"e_1_2_12_18_1","unstructured":"www.canadianneonatalnetwork.org\/portal\/Portals\/0\/CNN%20Manuals\/CNN%20Manual_20230308.pdf"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.37757\/MR2021.V23.N1.7"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2022.2163135"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15331"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2023-002208"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.14295\/rp.v55i3.234"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.35663\/amp.2022.394.2441"},{"issue":"2","key":"e_1_2_12_25_1","first-page":"70","article-title":"Descripci\u00f3n de una cohorte de pacientes neonatos con diagn\u00f3stico de asfixia perinatal, tratados con hipotermia terap\u00e9utica","volume":"32","author":"Manotas H","year":"2017","journal-title":"Perinatol Reprod Hum 2018"},{"issue":"2","key":"e_1_2_12_26_1","first-page":"1","article-title":"Desenlaces tempranos del manejo de la asfixia perinatal con Cool\u2010Cap\u00ae y manta","volume":"64","author":"Ram\u00edrez\u2010Corredor A","year":"2022","journal-title":"Univ Med"},{"issue":"5","key":"e_1_2_12_27_1","first-page":"176","article-title":"Hipotermia terap\u00e9utica en reci\u00e9n nacidos con encefalopat\u00eda hip\u00f3xico\u2010isqu\u00e9mica","volume":"87","author":"Mart\u00ednez\u2010Hern\u00e1ndez A","year":"2020","journal-title":"Rev Mex Pediatr"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247229"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.18231\/j.ijmpo.2024.008"},{"issue":"3","key":"e_1_2_12_31_1","first-page":"1","article-title":"To cool or not to cool: a dilemma regarding the Helix study","volume":"79","author":"Fajardo CA","year":"2022","journal-title":"Bol Med Hosp Infant Mex"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-023-05885-y"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1771016"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/pxaa075"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-024-04987-6"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.17504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.17504","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.17504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:28:57Z","timestamp":1785436137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.17504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/apa.17504"],"URL":"https:\/\/doi.org\/10.1111\/apa.17504","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,18]]},"assertion":[{"value":"2024-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}