{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:59:52Z","timestamp":1785437992343,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Our aims were to describe the neurodevelopment of infants with congenital gastrointestinal malformations at 2\u2009years of age and to investigate the association between developmental delay and complex trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective cohort study\n                      <jats:italic>.<\/jats:italic>\n                      Infants operated on for oesophageal atresia, abdominal wall defects, intestinal malformation, congenital diaphragmatic hernia and anorectal malformation were analysed. Neurodevelopment was assessed using the Ages and Stages Questionnaire at 24\u2009months. The primary outcome was the presence of developmental delay, defined as ASQ\u201024\u2009months of total score\u2009\u2264\u2009185.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 118 patients, 11 (9%) had an ASQ\u201024\u2009months \u2264185. Factors associated with an ASQ\u201024\u2009months \u2264185 were earlier gestational age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045), longer invasive ventilation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046), longer parenteral nutrition (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043) and\u2009\u22652 hospitalisations in the first 2\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022). They had a significantly longer stay in the neonatal intensive care unit and subsequent hospitalisations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). After adjustment for prematurity and breastfeeding, this association remained statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nine per cent of children with a gastrointestinal malformation show a developmental delay at the age of two. A prolonged stay in the neonatal intensive care unit and subsequent hospitalisations are associated with an increased risk of neurodevelopmental disorders, while breastfeeding may have a protective effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.17523","type":"journal-article","created":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T08:48:02Z","timestamp":1733561282000},"page":"992-998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Complex trajectories are associated with neurological impairment in infants with congenital gastrointestinal malformations aged two"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8298-1828","authenticated-orcid":false,"given":"Manon","family":"Midavaine","sequence":"first","affiliation":[{"name":"Department of Neonatology Necker\u2010Enfants Malades University Hospital, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Vinit","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Surgery, Urology and Transplantation Necker\u2010Enfants Malades University Hospital, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Sartorius","sequence":"additional","affiliation":[{"name":"Department of Neonatology Necker\u2010Enfants Malades University Hospital, APHP  Paris France"},{"name":"UFR de M\u00e9decine Paris Cit\u00e9 University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Kermorvant\u2010Duchemin","sequence":"additional","affiliation":[{"name":"Department of Neonatology Necker\u2010Enfants Malades University Hospital, APHP  Paris France"},{"name":"UFR de M\u00e9decine Paris Cit\u00e9 University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Lapillonne","sequence":"additional","affiliation":[{"name":"Department of Neonatology Necker\u2010Enfants Malades University Hospital, APHP  Paris France"},{"name":"UFR de M\u00e9decine Paris Cit\u00e9 University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.05.050"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1343773"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2021.01.014"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207848"},{"key":"e_1_2_12_6_1","article-title":"Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE\u20102 cohort study","volume":"373","author":"Pierrat V","year":"2021","journal-title":"The BMJ"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-322158"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.12.015"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-000834"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-310777"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-021-04145-5"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsad025"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3583"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2798"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-305464"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225027"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020004"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-59"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(19)30149-9"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02390-5"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8090730"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.14204"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.02.015"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-023-05625-5"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133087"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doab054"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12206"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2018.02.064"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.17523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.17523","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.17523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:28:35Z","timestamp":1785436115000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.17523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,7]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/apa.17523"],"URL":"https:\/\/doi.org\/10.1111\/apa.17523","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,7]]},"assertion":[{"value":"2024-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}