{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:59:36Z","timestamp":1785437976935,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the indications, population characteristics and latency between short stature diagnosis to treatment with recombinant growth hormone (GH) therapy in a large cohort of children in Israel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective medical chart review of all children treated with GH for conditions associated with short stature in three central districts in Israel from 1 January 2010 to 31 December 2021. Data extracted from the medical files included demographics, time to diagnosis, treatment indications and GH therapy duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study group comprised 5148 children aged 1\u2009day to 17\u2009years. A total of 64.1% were diagnosed with idiopathic short stature (ISS), 31.1% with GH deficiency (GHD) and 2.5% with small\u2010for\u2010gestational age (SGA). Males were treated more than females (58.9% vs. 41.1%). The mean age at first documentation of short stature was 6.9\u2009\u00b1\u20093.5\u2009years. GH therapy was initiated at a mean age of 9.8\u2009\u00b1\u20093.3\u2009years. A total of 51.2% were of high socio\u2010economic status (SES); 78.2% were non\u2010ultraorthodox Jews, 13%, ultraorthodox Jews, and 8.8% were Arabs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Meticulous growth follow\u2010up from early childhood for all children, specifically females, those of low SES, and minorities is important to provide appropriate referral, treatment and final adult height outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.17535","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T09:24:33Z","timestamp":1733477073000},"page":"1043-1050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Growth hormone treatment in children in Israel: A large\u2010scale retrospective database study"],"prefix":"10.1111","volume":"114","author":[{"given":"Yael","family":"Reichenberg","sequence":"first","affiliation":[{"name":"Dan\u2010Petach Tikva District, Clalit Health Services  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Bello","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"},{"name":"The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes Schneider Children's Medical Center of Israel  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernice","family":"Oberman","sequence":"additional","affiliation":[{"name":"Dan\u2010Petach Tikva District, Clalit Health Services  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moryia","family":"Cohen","sequence":"additional","affiliation":[{"name":"Microbiology Unit Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avner Herman","family":"Cohen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"},{"name":"Pediatric Ambulatory Community Clinic  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1733-5395","authenticated-orcid":false,"given":"Vered","family":"Shkalim Zemer","sequence":"additional","affiliation":[{"name":"Dan\u2010Petach Tikva District, Clalit Health Services  Tel Aviv Israel"},{"name":"Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yapd.2022.03.005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-023-02716-3"},{"key":"e_1_2_12_4_1","article-title":"Identification, investigation, and treatment in a child with growth disorder and short stature: clinical guidelines","author":"Gur S","year":"2017","journal-title":"Isr Soc Pediatr Endocrinol"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2018.22"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4946.20.05821-1"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2021-0045"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502231"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.17458\/per.vol16.2018.ca.ghidiopathicshortstature"},{"key":"e_1_2_12_10_1","first-page":"2000","volume-title":"Endotext","author":"Yau M","year":"2023"},{"key":"e_1_2_12_11_1","unstructured":"Central Bureau of Statistics. 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