{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:36:08Z","timestamp":1772987768950,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The relationship between bronchiolitis and asthma is complex. We assessed whether patients admitted to a paediatric intensive care unit (PICU) with bronchiolitis had a greater risk of developing asthma than patients admitted to a paediatric ward.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively included children under 1\u2009year of age, who were hospitalised for bronchiolitis for the first time at the University Hospital of Caen, France, between 2010 and 2014. The children were divided into two groups: 89 were admitted to the paediatric ward and 89 were admitted to the PICU. We wanted to assess which group developed more asthma before 6\u2009years of age. The Global Initiative for Asthma definition was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age of the 178 children (55% boys) was 32 (interquartile range 19\u201356) days. We found that 35% of the PICU group and 19% of the ward group had asthma at 6\u2009years of age. The mean onset of symptoms was 3\u2009years earlier in the PICU group than the ward group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Both these findings were significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The severity of the first episode of bronchiolitis increased the risk of developing asthma symptoms. Regular follow\u2010ups are suggested for infants admitted to PICUs for bronchiolitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.17565","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T23:47:58Z","timestamp":1735861678000},"page":"1283-1290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The severity of the first occurrence of bronchiolitis increased the risk of developing asthma symptoms"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7190-2816","authenticated-orcid":false,"given":"Cedric","family":"Agossah","sequence":"first","affiliation":[{"name":"Department of Paediatrics CHU de Caen  Caen France"},{"name":"School of Medicine University Caen Normandie  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Marie","sequence":"additional","affiliation":[{"name":"Department of Paediatrics CHU de Caen  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmine","family":"Bendoukha","sequence":"additional","affiliation":[{"name":"Department of Biostatistics CHU de Rouen  Rouen France"},{"name":"School of Medicine University Rouen Normandie  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecile","family":"Vallet","sequence":"additional","affiliation":[{"name":"Department of Paediatrics CHU de Caen  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Brouard","sequence":"additional","affiliation":[{"name":"Department of Paediatrics CHU de Caen  Caen France"},{"name":"School of Medicine University Caen Normandie  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2059-9888","authenticated-orcid":false,"given":"David","family":"Brossier","sequence":"additional","affiliation":[{"name":"School of Medicine University Caen Normandie  Caen France"},{"name":"Paediatric Intensive Care Unit CHU de Caen  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2005.05.010"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.10.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1111723"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13741"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02293-2021"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.15586\/aei.v51i3.788"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00156-7"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21557"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-016-0056-4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0335-7457(05)80280-1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101257"},{"key":"e_1_2_11_13_1","unstructured":"HAS.Prise en charge du premier \u00e9pisode de bronchiolite a\u00efgue chez le nourrisson de moins de 12 mois (management of the first episode of acute bronchiolitis in infants under 12 months of age).https:\/\/www.has\u2010sante.fr\/upload\/docs\/application\/pdf\/2019\u201011\/hascnpp__bronchiolite_argumentaire_2019_vd.pdf2019."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_11_15_1","unstructured":"Global Initiative for Asthma (GINA).Global strategy for asthma management and prevention.https:\/\/ginasthma.org\/gina\u2010reports\/2022."},{"key":"e_1_2_11_16_1","unstructured":"Sant\u00e9 publique France.Asthme (asthma).https:\/\/www.santepubliquefrance.fr\/maladies\u2010et\u2010traumatismes\/maladies\u2010et\u2010infections\u2010respiratoires\/asthme\/donnees\/#tabs2020."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.02.021"},{"key":"e_1_2_11_18_1","first-page":"392","article-title":"Respiratory 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