{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:36:43Z","timestamp":1772987803780,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21nf0101636"],"award-info":[{"award-number":["JP21nf0101636"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["21AA2007"],"award-info":[{"award-number":["21AA2007"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["22AA2003"],"award-info":[{"award-number":["22AA2003"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Some countries are hesitant to implement routine varicella vaccination for children because of concerns over the exogenous boosting hypothesis, which suggests that vaccinating children may increase herpes zoster cases in adults. However, substantial evidence supporting this hypothesis is lacking. This study assessed the association between a child's varicella vaccination status and herpes zoster occurrence in adults in the same household.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analysed data from a Japanese city between April 2014 and December 2022. We included individuals aged \u2265\u200918\u2009years living in households with a single child eligible for varicella vaccination. Children's vaccination status was categorised as unvaccinated, first\u2010dose vaccinated or second\u2010dose vaccinated. Cox regression analysis with time\u2010dependent exposure assessed herpes zoster incidence in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 4023 eligible individuals, 136 (3.4%) developed herpes zoster over the median follow\u2010up of 552\u2009days. Neither the first nor the second dose of varicella vaccine in children was significantly associated with an increased risk of herpes zoster in adults (hazard ratio 1.24 [95% confidence interval, 0.69\u20132.23] for the first dose and 1.51 [0.87\u20132.62] for the second dose).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Varicella vaccination in households with a single child was not significantly associated with an increased risk of herpes zoster in adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.17582","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T09:32:27Z","timestamp":1736760747000},"page":"1392-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Child Varicella Vaccination and Zoster in Household Adults: A Retrospective Japanese Cohort Study"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1265-6835","authenticated-orcid":false,"given":"So","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Eat\u2010Loss Medicine, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Sasabuchi","sequence":"additional","affiliation":[{"name":"Department of Real\u2010World Evidence, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Michihata","sequence":"additional","affiliation":[{"name":"Cancer Prevention Center Chiba Cancer Center Research Institute  Chuo\u2010ku, Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Bioinformatics, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010108\u20102\u2010221"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(52)91357\u20103"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591576505800106"},{"key":"e_1_2_11_5_1","first-page":"287","article-title":"Chicken Pox\/Varicella Zoster and Vaccine in Japan","volume":"34","author":"National Institute of Infectious Diseases","year":"2013","journal-title":"IASR"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1343669"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy1099"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0950268800050019"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2018.07.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.11.057"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1788861"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.es2014.19.41.20926"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac255"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2019.1646129"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6987"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)60828\u20103"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.02.058"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.08.048"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010022\u201000744\u20108"},{"key":"e_1_2_11_20_1","first-page":"6","volume-title":"The Green Book","author":"UK Health Security Agency","year":"2024"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00397\u201008"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_11_23_1","volume-title":"Applied Survival Analysis: Regression Modelling of Time to Event Data","author":"Hosmer D. 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