{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:31:57Z","timestamp":1771331517583,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["327654276"],"award-info":[{"award-number":["327654276"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1315"],"award-info":[{"award-number":["SFB 1315"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe the long\u2010term neurodevelopmental outcomes of asphyxiated neonates treated with hypothermia in association with neonatal magnetic resonance imaging (MRI) findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated, retrospectively, clinical and radiological single\u2010centre data at 0, 2, and 5\u2009years of age of 53 asphyxiated neonates born between 2005 and 2015. Neonatal cranial MRI was re\u2010evaluated using the Weeke score ranging from 0 (normal finding) to 55 (cerebral devastation) by a single neuroradiologist blinded to patient outcomes. Neurodevelopmental outcomes were evaluated using the Bayley Scales of Infant Development (BSID) at 2\u2009years, and tests assessing intellectual performance at 5\u2009years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 191 asphyxiated neonates treated with hypothermia, 53 returned for their 5\u2010year follow\u2010up. There were 10 children with MRI scores \u2265\u200910, all of whom had epilepsy, 9 had severe cognitive impairment, and 9 had cerebral palsy. In contrast, MRI scores &lt;\u200910 were poorly predictive of later development. BSID at 2\u2009years of age showed good correlation with IQ scores at 5\u2009years of age (<jats:italic>R<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u2009=\u20090.58, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Weeke score can be used to identify severely impaired children in the neonatal period. In contrast, the neurocognitive test results at 2\u2009years of age were indicative of mild or moderate impairment at 5\u2009years of age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.17598","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T05:32:46Z","timestamp":1738128766000},"page":"1553-1561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictors for Development of Asphyxiated Neonates Treated With Therapeutic Hypothermia"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-0125","authenticated-orcid":false,"given":"Fabienne","family":"K\u00fchne","sequence":"first","affiliation":[{"name":"Center for Chronically Sick Children Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Neonatology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Pediatric 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Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"German Heart Center Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Grigoryev","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-7292","authenticated-orcid":false,"given":"Yee Lee","family":"Shing","sequence":"additional","affiliation":[{"name":"Department of Psychology Goethe Universit\u00e4t Frankfurt am Main  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8738-3133","authenticated-orcid":false,"given":"Claudia","family":"Buss","sequence":"additional","affiliation":[{"name":"German Center for Child and Adolescent Health (DZKJ), partner site Berlin  Berlin Germany"},{"name":"Institute for Medical Psychology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Pediatrics, Development, Health and Disease Research Program University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-414X","authenticated-orcid":false,"given":"Christoph","family":"B\u00fchrer","sequence":"additional","affiliation":[{"name":"Department of Neonatology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"German Center for Child and Adolescent Health (DZKJ), partner site Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9454-206X","authenticated-orcid":false,"given":"Angela M.","family":"Kaindl","sequence":"additional","affiliation":[{"name":"Center for Chronically Sick Children Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin 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