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Local follow\u2010up per national guidelines.<\/jats:p>\n Subjects: 134 infants born at 23\u201327\u2009weeks' gestation with a birth weight\u2009<\u20091000\u2009g.<\/jats:p>\n \n Intervention: Daily enteral supplementation with placebo or Limosilactobacillus reuteri DSM 17938 (2.5\u2009\u00d7\u200910\n 8<\/jats:sup>\n colony forming units), from within 72\u2009h after birth to postmenstrual week 35\u201336.\n <\/jats:p>\n Main outcome measures: Bayley\u2010III developmental assessment and auxology at 24\u2009\u00b1\u20093\u2009months corrected age.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Follow\u2010up data were available for 110 of 117 surviving participants, and 85 children were assessed with Bayley\u2010III. Mean language score after supplementation with\n \n L. reuteri<\/jats:italic>\n <\/jats:styled-content>\n was 90 (95% confidence interval: 85\u201395) compared to 83 in the placebo group (95% CI: 78\u201388),\n p<\/jats:italic>\n \u2009=\u20090.04. No other significant differences in neurodevelopment or growth were observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Supplementation with\n \n L. reuteri<\/jats:italic>\n <\/jats:styled-content>\n in extremely preterm infants was not associated with altered growth nor general neurodevelopmental outcomes at 2\u2009years while language index was improved. This is interesting given previously reported early improved growth of head circumference.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apa.70030","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:45:08Z","timestamp":1739425508000},"page":"1817-1824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neurodevelopment and Growth 2\u2009Years After Probiotic Supplementation in Extremely Preterm Infants: A Randomised Trial"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7424-6659","authenticated-orcid":false,"given":"Erik","family":"Wejryd","sequence":"first","affiliation":[{"name":"Division of Children's and Women's Health, Department of Biomedical and Clinical Sciences Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Department of Paediatrics Vrinnevi Hospital Norrk\u00f6ping 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