{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T21:21:59Z","timestamp":1762809719537,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Extreme prematurity is a multi\u2010organ medical emergency. Most high\u2010profile studies in this field are done as single\u2010intervention randomised controlled trials (RCTs), often yielding negative or inconclusive results. Given the complexity of extreme prematurity, we suggest applying future RCTs using a bundle\u2010of\u2010care approach. Such an approach should take into consideration: (a) results from RCTs and meta\u2010analyses demonstrating a positive, albeit non\u2010significant effect of a specific intervention; (b) fundamental physiological aspects unique to the neonatal period; and (c) specific interventions aiming for a common outcome. Complementing and possibly supplanting the gold standard of single\u2010intervention RCTs with a bundle\u2010of\u2010care approach may open new scientific avenues in neonatology.<\/jats:p>","DOI":"10.1111\/apa.70057","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:27:05Z","timestamp":1741739225000},"page":"1550-1552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bundle\u2010Of\u2010Care vs. Single\u2010Intervention <scp>RCTs<\/scp> in Neonatology: Clinical Research in Neonatology\u2014Quo Vadis?"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2336-6359","authenticated-orcid":false,"given":"Sascha","family":"Meyer","sequence":"first","affiliation":[{"name":"St\u00e4dtisches Klinikum Karlsruhe Franz\u2010Lust Klinik f\u00fcr Kinder\u2010 Und Jugendmedizin  Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-2728","authenticated-orcid":false,"given":"Martin","family":"Poryo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Saarland University Medical Center  Homburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel R.","family":"Franz","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Interdisciplinary Pediatric Sleep Medicine, and Center for Pediatric Clinical Studies (CPCS) Eberhard Karls University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian F.","family":"Poets","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Interdisciplinary Pediatric Sleep Medicine, and Center for Pediatric Clinical Studies (CPCS) Eberhard Karls University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2020.105040"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2017.08.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60664-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00204-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(24)00073-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1907423"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.101146"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528914"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002971.pub6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013271.pub2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2013.03.002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010018\u20101017\u20107"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.14140"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018\u20100201"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03694-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2021.6619"},{"issue":"10","key":"e_1_2_6_18_1","first-page":"629","article-title":"The EPIQ Evidence Reviews\u2014Practical Tools for an Integrated Approach to Knowledge Translation","volume":"16","author":"Lee S. K.","year":"2011","journal-title":"Paediatrics & Child Health"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-0932-4"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01899-7"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:08:41Z","timestamp":1760612921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,10]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/apa.70057"],"URL":"https:\/\/doi.org\/10.1111\/apa.70057","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"type":"print","value":"0803-5253"},{"type":"electronic","value":"1651-2227"}],"subject":[],"published":{"date-parts":[[2025,3,10]]},"assertion":[{"value":"2025-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}