{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:44:10Z","timestamp":1792003450281,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This work was performed to assess the impact of nirsevimab immunisation on acute bronchiolitis hospitalisations during nearly the entire 2023\u20132024 epidemic year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An observational, multicentre, prospective study was conducted from 1 September 2021 to 15 June 2024 across 20 hospitals in two Spanish regions. Infants up to 12\u2009months old admitted for acute bronchiolitis were included. Demographic, clinical and microbiological data were analysed across three epidemic years (2021\u20132022, 2022\u20132023 and 2023\u20132024). Statistical analyses were performed to evaluate the effectiveness of nirsevimab in preventing respiratory syncytial virus (RSV)\u2010associated hospitalisations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 2656 patients were included. Bronchiolitis hospitalisations significantly declined in the post\u2010nirsevimab epidemic year compared with previous years. The 2023\u20132024 season displayed a bimodal distribution, with the first peak dominated by RSV cases and the second by rhinoviruses and metapneumovirus. The proportion of RSV\u2010associated bronchiolitis hospitalisations decreased by 20%\u201330%, while rhinovirus\u2010 and metapneumovirus\u2010associated bronchiolitis cases increased by 10%\u201320%. The effectiveness of nirsevimab in preventing RSV\u2010associated admissions was estimated to be approximately 70%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nirsevimab immunisation significantly reduced RSV\u2010associated bronchiolitis admissions, though an increase in rhinovirus\u2010 and metapneumovirus\u2010associated cases was observed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70066","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T02:38:14Z","timestamp":1743215894000},"page":"1963-1976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Nirsevimab Immunisation Significantly Reduces Respiratory Syncytial Virus\u2010Associated Bronchiolitis Hospitalisations and Alters Seasonal Patterns"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-4982","authenticated-orcid":false,"given":"Juan Manuel","family":"Rius\u2010Peris","sequence":"first","affiliation":[{"name":"Hospital Universitario Virgen de la Luz  Cuenca Spain"},{"name":"Research Group in Electronic Biomedical and Telecommunication Engineering, University of Castilla\u2010La Mancha  Cuenca Spain"},{"name":"Grupo de Investigaci\u00f3n en Ingenier\u00eda Biom\u00e9dica Instituto de Investigaci\u00f3n Sanitariade Castilla\u2010La Mancha (IDISCAM)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Palomo\u2010Atance","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Ciudad Real  Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Muro\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Llorente\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Guadalajara  Guadalajara Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Murcia\u2010Clemente","sequence":"additional","affiliation":[{"name":"Hospital del Vinalopo\u00b4  Elche, Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Alcaraz","sequence":"additional","affiliation":[{"name":"Research Group in Electronic Biomedical and Telecommunication Engineering, University of Castilla\u2010La Mancha  Cuenca Spain"},{"name":"Grupo de Investigaci\u00f3n en Ingenier\u00eda Biom\u00e9dica Instituto de Investigaci\u00f3n Sanitariade Castilla\u2010La Mancha (IDISCAM)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1715852"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2016.10.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01016-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17199"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1913556"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2110275"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20104642(22)00321\u20102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309189"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2023.09.006"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17301"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2024.29.6.2400046"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.14175"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-024-05634-z"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00215-9"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12101160"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1441786"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12040383"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2024.29.4.2400033"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13311"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20104642(24)00171\u20108"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12050549"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7309a4"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2021.06.008"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1413456"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-0842"},{"issue":"4","key":"e_1_2_11_27_1","first-page":"264","article-title":"Recommendations of the Spanish Society of Neonatology for the Prevention of Severe Respiratory Syncytial Virus Infections With Nirsevimab, for the 2023\u20102024 Season","volume":"99","author":"S\u00e1nchez Luna M.","year":"2023","journal-title":"Anales de Pediatr\u00eda"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2022.01.005"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infpip.2024.100399"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-019-00494-6"},{"key":"e_1_2_11_31_1","unstructured":"Ministry of Health \u201cRecommendations for Passive Immunization to Prevent Severe RSV Disease in the Pediatric Population. Public Health Commission of the Interterritorial Council of the National Health System\u201d(2024) https:\/\/www.sanidad.gob.es\/areas\/promocionPrevencion\/vacunaciones\/comoTrabajamos\/docs\/VRS_infantil.pdf."},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2024-327153"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.101007"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimce.2024.04.014"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2024-066584"},{"key":"e_1_2_11_36_1","unstructured":"European Centre for Disease Prevention and Control \u201cIntensified Circulation of Respiratory Syncytial Virus (RSV) and Associated Hospital Burden in the EU\/EEA\u201412 December 2022 \u201d(2022) ECDC: Stockholm."}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.70066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:53:43Z","timestamp":1769860423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/apa.70066"],"URL":"https:\/\/doi.org\/10.1111\/apa.70066","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]},"assertion":[{"value":"2024-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}