{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:54:03Z","timestamp":1771847643938,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["0176\u201000020B"],"award-info":[{"award-number":["0176\u201000020B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005111","name":"Rigshospitalet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>There is limited evidence on the use of oral doxycycline in young children. We evaluated the feasibility and effectiveness of doxycycline in children under 9\u2009years with neuroborreliosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included all children under 9\u2009years of age treated for neuroborreliosis in the Capital Region of Denmark from 2019 to 2023. Patients were identified through\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Borrelia burgdorferi<\/jats:italic>\n                      <\/jats:styled-content>\n                      antibody tests and International Classification of Disease, 10th revision codes. Outcomes were change of treatment route, intolerable adverse effects of oral doxycycline, progression of symptoms after treatment cessation, continuous symptoms of neuroborreliosis exceeding 6 months, and relapse of neuroborreliosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 116 children, 63 (54%) received doxycycline initially, 4 (6%) of whom switched to intravenous treatment due to adverse effects or symptom worsening during treatment. Of 46 (40%) receiving intravenous antibiotics followed by doxycycline, 45 (98%) completed the remaining treatment on doxycycline. Seven (6%) patients received intravenous antibiotics only. Of 109 patients receiving doxycycline, two (2%) experienced photosensitivity rash. Symptoms lasting over 6 months were observed in two patients. No patients had symptom progression or relapse during the follow\u2010up period (median 41\u2009months, range 12\u201366).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oral doxycycline was effective and feasible in children under 9\u2009years with neuroborreliosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70085","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T19:12:19Z","timestamp":1743880339000},"page":"2061-2065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral Doxycycline Was a Safe and Feasible Treatment in Young Children With Neuroborreliosis"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9618-3483","authenticated-orcid":false,"given":"Joakim","family":"Bloch","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences Copenhagen University  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisbeth","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences Copenhagen University  Copenhagen Denmark"},{"name":"Department of Children and Adolescents Copenhagen University Hospital \u2013 Herlev and Gentofte  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja","family":"Vissing","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan Peter","family":"Glenth\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Children and Adolescents Copenhagen University Hospital \u2013 North Zealand Hospital  Hilleroed Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences Copenhagen University  Copenhagen Denmark"},{"name":"Department of Children and Adolescents Copenhagen University Hospital \u2013 Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred Peter","family":"Born","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Mette","family":"Lebech","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences Copenhagen University  Copenhagen Denmark"},{"name":"Department of Infectious Diseases Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrikka","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences Copenhagen University  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/HPEDS.2021\u2010005909"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1468\u20101331.2009.02862.X"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ENE.16034"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(62)91840\u20108"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(69)91787\u20105"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/PEDS.2023\u2010061350\/191428"},{"key":"e_1_2_10_8_1","first-page":"975","volume-title":"Red Book: 2024\u20132027 Report of the Committee on Infectious Diseases","author":"Tetracyclines","year":"2024"},{"key":"e_1_2_10_9_1","unstructured":"\u201cTreatment of Lyme Disease \u2013 UpToDate \u201d2025 https:\/\/www.uptodate.com\/contents\/treatment\u2010of\u2010lyme\u2010disease?search=doxycyclie%20borrelia&source=search_result&selectedTitle=12%7E150&usage_type=default&display_rank=12#H319783157."},{"key":"e_1_2_10_10_1","volume-title":"Facialisparese hos b\u00f8rn","author":"Bybeck A.","year":"2021"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/S15010\u2010023\u201002005\u2010Y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/APA.17414"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACM.0000000000000270"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028019863796"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12887\u2010022\u201003335\u2010W"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/JPIDS\/PIY072"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0B013E31817FD423"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ENE.14962"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537\u2010198511000\u201000009"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004128"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/S40264\u2010019\u201000806\u20105"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.70085","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:53:48Z","timestamp":1769860428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,5]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/apa.70085"],"URL":"https:\/\/doi.org\/10.1111\/apa.70085","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,5]]},"assertion":[{"value":"2025-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}