{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:08:33Z","timestamp":1783840113976,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002301","name":"Eesti Teadusagentuur","doi-asserted-by":"publisher","award":["PRG1428"],"award-info":[{"award-number":["PRG1428"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to analyse the incidence and clinical presentation of childhood CD from 2011 to 2020 in Estonia and to compare the incidence with earlier published results of a 35\u2010year period (1976\u20132010).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data was collected retrospectively about children up to 19\u2009years of age who were newly diagnosed with CD from 2011 to 2020 in all of Estonia. CD was diagnosed mostly by biopsy and in only two cases by serology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 2011 to 2020, 189 new CD cases were diagnosed (113 girls, 60%, M\/F ratio 1:1.49). The median age at diagnosis was 8.6\u2009years. For comparison, from 1976 to 2010, the median age was 2.3\u2009years. There were no differences between boys and girls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.93). Most frequently, the patients had atypical gastrointestinal symptoms. The incidence rate per 100\u2009000 person\u2010years in 2011\u20132020 was 6.89 (95% CI: 5.94\u20137.94). For comparison, in 1976\u20131980, the incidence rate per 100\u2009000 person\u2010years was 0.1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The median age at diagnosis increased markedly during the study period. From 1976 onward, there has been almost a 70\u2010fold increase in the incidence rate of CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70092","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T23:39:01Z","timestamp":1744414741000},"page":"2219-2224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Has the Rise of Celiac Disease Incidence in Estonian Children Stopped?"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0636-2056","authenticated-orcid":false,"given":"K\u00e4rt","family":"Simre","sequence":"first","affiliation":[{"name":"Children's Clinic Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heti","family":"Pisarev","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health University of Tartu  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u2010Liis","family":"Kumm","sequence":"additional","affiliation":[{"name":"Tallinn Children's Hospital  Tallinn Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Kaivo","sequence":"additional","affiliation":[{"name":"Tallinn Children's Hospital  Tallinn Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oivi","family":"Uibo","sequence":"additional","affiliation":[{"name":"Children's Clinic Tartu University Hospital  Tartu Estonia"},{"name":"Department of Pediatrics University of Tartu  Tartu 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