{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:26:11Z","timestamp":1788067571877,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015474","name":"Department of Geological Sciences, University of Alabama","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015474","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009571","name":"Institut de Veille Sanitaire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010102","name":"Institut National de Pr\u00e9vention et d'\u00c9ducation pour la Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008018","name":"Mutuelle G\u00e9n\u00e9rale de l'Education Nationale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To describe cardiometabolic health profiles at age 5\u20136\u2009years, their correlation with age at adiposity rebound (AR) and associations with maternal hyperglycaemia at 24\u201328\u2009weeks' gestation (gestational diabetes, fasting (FPG), 1\u2010hour postload plasma glucose), in mothers without pre\u2010existing diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>BMI, %fat mass, blood pressure (BP), FPG, HOMA\u2010IR and lipids were assessed in children from the EDEN study, a French bicentric birth cohort. Sex\u2010specific cardiometabolic health profiles were derived using principal component analysis and examined against age at AR with Pearson's correlation. Associations with maternal hyperglycaemia were studied using multiple linear regressions adjusted for parental factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 674 children, four profiles were identified per sex: \u2018higher adiposity, BP, insulin resistance (IR)\u2019; \u2018higher BP and lower adiposity\u2019; \u2018higher IR and lower adiposity\u2019; \u2018higher triglycerides and LDL\u2010c and lower HDL\u2010c\u2019. The profile of \u2018higher adiposity, BP, IR\u2019 was correlated with earlier age at AR in both sexes. Higher maternal FPG was positively associated with the profile of \u2018higher adiposity, BP, IR\u2019 in boys and \u2018higher triglycerides and LDL\u2010c and lower HDL\u2010c\u2019 in girls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u2018Higher adiposity, BP, IR\u2019 profile at age 5\u20136\u2009years was associated with earlier age of adiposity rebound. Marginal associations were observed with maternal hyperglycaemia in pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70106","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T04:10:17Z","timestamp":1745381417000},"page":"2287-2297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Adverse Influence of Maternal Glycaemia During Pregnancy on Offspring's Cardiometabolic Health Profiles"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7472-5042","authenticated-orcid":false,"given":"Wen Lun","family":"Yuan","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, INSERM, INRAE Centre for Research in Epidemiology and StatisticS (CRESS)  Paris France"},{"name":"Singapore Institute for Clinical Sciences Agency for Science, Technology and Research (A*STAR)  Singapore 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