{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:55:04Z","timestamp":1787230504740,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Presence of deep ulcerations (\n                      <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                      ) at diagnosis seems to be predictive of a more severe phenotype in adult Crohn's disease (\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      ). The aim of our study was to investigate if the presence of\n                      <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                      at diagnosis was associated with a more severe disease course over time in children.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this monocentric retrospective study, we analysed data from paediatric patients with a new diagnosis of\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      from 2009 to 2017. Clinical, laboratory data, treatments and complications were recorded for each patient at diagnosis and at 1, 3 and 5\u2009years of follow\u2010up. Patients were compared according to the presence or absence of\n                      <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                      on colonoscopy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 116 patients included in the study, 52 patients had\n                      <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                      at diagnosis. Comparison showed an increased risk for patients with\n                      <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                      to develop abdominal abscesses (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) and to experience more relapses (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) at 1\u2009year. At 3 and 5\u2009years, there was no longer any difference between groups. The time from diagnosis to first anti\u2010\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      alpha was shorter in\n                      <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                      patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The presence of\n                      <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                      at diagnosis is associated with more complications during the first year of follow\u2010up but not after, due to a more active therapeutic management.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70115","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T11:49:11Z","timestamp":1746618551000},"page":"2329-2336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Outcome of Paediatric Crohn's Disease Patients With Deep Ulcerations at Diagnosis"],"prefix":"10.1111","volume":"114","author":[{"given":"Monica S.","family":"Ronconi","sequence":"first","affiliation":[{"name":"Service de Gastro\u2010Ent\u00e9rologie et Nutrition P\u00e9diatrique, Centre de R\u00e9f\u00e9rence Des Maladies Rares Digestives (MARDI), Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants Malades Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Neuraz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Imagine Institute, APHP  Paris 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