{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:24:13Z","timestamp":1792880653658,"version":"4.5.0"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This review examines low\u2010cost interventions for reducing neonatal mortality and morbidity in low\u2010 and middle\u2010income countries (LMICs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic PubMed search and neonatal care data from World Health Organization (2014\u20132024) were used to revise interventions including prenatal care, early essential newborn care (EENC), resuscitation and therapeutic hypothermia, Kangaroo mother care (KMC), respiratory support, breastfeeding, sepsis prevention, safe neonatal transfer, neonatal network in LMICs and suggestions for improvement. Out of 9295 initially identified articles, 252 studies were selected as relevant to the research objectives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In LMICs, the use of antenatal corticosteroids and magnesium sulfate remains limited in routine obstetric practice. Although EENC, KMC and early breastfeeding significantly reduce neonatal mortality, these interventions are under\u2010prioritised and insufficiently implemented. Neonatal resuscitation and respiratory support are constrained by inadequate equipment and a shortage of trained healthcare personnel. Healthcare\u2010associated sepsis, compounded by antibiotic resistance, continues to strain neonatal intensive care units. Additionally, unsafe neonatal transfers and poor coordination among different levels of neonatal care highlight the need for better integration within regional health systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To reduce neonatal mortality and enhance care in LMICs, systematic training, effective implementation and the sustainable delivery of proven, low\u2010cost, high\u2010impact interventions are urgently needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70133","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:39:21Z","timestamp":1747193961000},"page":"2124-2132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Review of Low\u2010Cost Interventions for Reducing Neonatal Mortality and Morbidity in Low\u2010 and Middle\u2010Income Countries"],"prefix":"10.1111","volume":"114","author":[{"given":"Le Thi","family":"Huynh","sequence":"first","affiliation":[{"name":"Neonatal Unit Da Nang Hospital for Women and Children  Da Nang Vietnam"},{"name":"Faculty of Nursing Da Nang University of Medical Technology &amp; Pharmacy  Da Nang Vietnam"},{"name":"Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University Belgium and Neonatal Intensive Care Unit, University Hospitals Ghent  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7729-6063","authenticated-orcid":false,"given":"Hoang Thi","family":"Tran","sequence":"additional","affiliation":[{"name":"Neonatal Unit Da Nang Hospital for Women and Children  Da Nang Vietnam"},{"name":"Department of Pediatrics, School of Medicine and Pharmacy The University of Da Nang  Da Nang Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Vanhaesebrouck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University Belgium and Neonatal Intensive Care Unit, University Hospitals Ghent  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"UNICEF \u201cNeonatal Mortality \u201d (2023) https:\/\/data.unicef.org\/topic\/child\u2010survival\/neonatal\u2010mortality\/."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)61651\u20102"},{"key":"e_1_2_10_4_1","unstructured":"World Health Organization \u201cRecommendations for Care of the Preterm or Low\u2010Birth\u2010Weight Infant \u201d (2022) WHO."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2022.3951"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022398"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60580-8"},{"key":"e_1_2_10_8_1","first-page":"2022","volume-title":"Third Biennial Progress Report: 2018\u20132020 (Action Plan for Health Newborn Infants in the Western Pacific Region: 2014\u20132020)","author":"World Health Organization Western Pacific Region","year":"2022"},{"issue":"5","key":"e_1_2_10_9_1","article-title":"Magnesium Sulphate for Women at Risk of Preterm Birth for Neuroprotection of the Fetus","volume":"5","author":"Shepherd E. 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