{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:08:35Z","timestamp":1783840115898,"version":"3.55.0"},"reference-count":79,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000147","name":"Canadian Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We developed a living systematic review (LSR) that will continuously map the safety and reported benefit data related to cannabinoid use for medical purposes in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE, Embase, PsycInfo, and the Cochrane Library were searched from inception to April 2023. Studies involving at least one child &lt;\u200918\u2009years who was administered plant\u2010derived or pharmaceutical cannabinoids as an intervention or treatment for medical conditions were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 37\u2009189 identified citations, 276 studies were included: 84 interventional, 131 observational, 54 surveys, and 7 qualitative studies. Among interventional and observational studies, common indications for cannabinoids in children were refractory epilepsy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009146 studies, 188\u2009726 participants), cancer and cancer symptoms (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930 studies, 208\u2009753 participants), and autism spectrum disorder (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918 studies, 1285 participants). Common cannabinoids identified in interventional studies were purified cannabidiol (CBD) (78.6%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200966 studies, 5235 participants) with dose range of 2\u201350\u2009mg\/kg\/day, tetrahydrocannabinol (6%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095 studies, 148 participants) with dose range of 2.5\u201310\u2009mg\/day (max dose of tetrahydrocannabinol in nabiximols 32.4\u2009mg) and nabilone (6%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095 studies, 267 participants) with dose range of 0.5\u20132\u2009mg\/day. In randomised controlled trials, purified cannabidiol was reported to reduce seizure frequency ranging between 30% and 50%. Common adverse events (&gt;\u200920% studies) in studies enrolling children were somnolence, diarrhoea, vomiting, and decreased appetite.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings will continue to be updated to inform practice and reveal knowledge gaps for future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70140","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:35:32Z","timestamp":1748478932000},"page":"2148-2159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cannabinoids for Medical Purposes in Children: A Living Systematic Review"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8924-8242","authenticated-orcid":false,"given":"Manik","family":"Chhabra","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omaymah","family":"Abulannaz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"},{"name":"Department of Pharmacology, Faculty of Medicine Jordan University of Science and Technology  Ar\u2010Ramtha Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00ea\u2010Linh","family":"L\u00ea","sequence":"additional","affiliation":[{"name":"Neil John Maclean Health Sciences Library, University of Manitoba  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Mansell","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Nutrition, University of Saskatchewan  Saskatoon Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Finkelstein","sequence":"additional","affiliation":[{"name":"Divisions of Emergency Medicine and Clinical Pharmacology and Toxicology Hospital for Sick Children, University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Huntsman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"},{"name":"Children's Hospital Research Institute of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"issue":"3","key":"e_1_2_14_2_1","first-page":"180","article-title":"Medicinal Cannabis: History, Pharmacology, and Implications for the Acute Care Setting","volume":"42","author":"Bridgeman M. 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