{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:55:48Z","timestamp":1772891748097,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess urinalysis (UA) accuracy for the diagnosis of bacteremic urinary tract infections (UTI) in young infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multi\u2010center retrospective study collecting 2008\u20132022 data of infants 0\u20133\u2010month\u2010old with bacteremic UTI (same pathogen in urine and blood).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 110 infants with bacteremic UTI, 64% were male and the median age was 21\u2009days; 85% were\u2009\u2264\u20092\u2009months of age. Fever\u2009\u2265\u200938\u00b0C was evident in 80% and 2% had hypothermia. Gram\u2010negative bacteria were cultured in 96%,\n                      <jats:italic>E. coli<\/jats:italic>\n                      in 72%, and\n                      <jats:italic>Klebsiella<\/jats:italic>\n                      in 18%. A total of 19 of the 110 infants (17%) had a normal UA (negative leukocyte esterase and negative nitrites). The sensitivity of abnormal UA for UTI diagnosis was 83% (95% confidence interval 76%\u201390%); 95% of the normal UA group had Gram\u2010negative pathogens:\n                      <jats:italic>E. coli<\/jats:italic>\n                      in 58% and\n                      <jats:italic>Klebsiella<\/jats:italic>\n                      in 26%. In comparing infants with abnormal and normal UA, no differences in age, sex, rate of febrile infants, and pathogens were noted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The accuracy of UA for identification of 0\u20133\u2010month\u2010old infants with bacteremic UTI is limited. Bacteremic UTI with a normal UA occurred in both genders, various ages, and pathogens. Relying solely on UA for ruling out UTI in 0\u20133\u2010month\u2010old infants may lead to significant underdiagnosis with a potential increase in morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70143","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:28:15Z","timestamp":1747726095000},"page":"2577-2581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Urinalysis Accuracy for Diagnosis of Bacteremic Urinary Tract Infections in 0\u20133\u2010Month\u2010Old Infants"],"prefix":"10.1111","volume":"114","author":[{"given":"Hend","family":"Heno","sequence":"first","affiliation":[{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shereen","family":"Shehadeh","sequence":"additional","affiliation":[{"name":"Carmel Medical Center  Haifa Israel"},{"name":"Ruth and Bruce Rappaport Faculty of Medicine  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadas","family":"Shasha\u2010Lavsky","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"},{"name":"Galilee Medical Center  Nahariya Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asaf","family":"Lebel","sequence":"additional","affiliation":[{"name":"Ruth and Bruce Rappaport Faculty of Medicine  Haifa Israel"},{"name":"HaEmek Medical Center  Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doua","family":"Bakry","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"},{"name":"Ziv Medical Center  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Bamberger","sequence":"additional","affiliation":[{"name":"Ruth and Bruce Rappaport Faculty of Medicine  Haifa Israel"},{"name":"Bnai Zion Medical Center  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keren","family":"Nathan","sequence":"additional","affiliation":[{"name":"Ruth and Bruce Rappaport Faculty of Medicine  Haifa Israel"},{"name":"Bnai Zion Medical Center  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Meir","sequence":"additional","affiliation":[{"name":"Ruth and Bruce Rappaport Faculty of Medicine  Haifa Israel"},{"name":"Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadia","family":"Hassan","sequence":"additional","affiliation":[{"name":"Ruth and Bruce Rappaport Faculty of Medicine  Haifa Israel"},{"name":"Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Nasrallah","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"},{"name":"Saint Vincent de Paul French Hospital  Nazareth Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said Abo","family":"Zaid","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"},{"name":"Tzafon Medical Center  Poriya Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8006-5845","authenticated-orcid":false,"given":"Daniel","family":"Glikman","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"},{"name":"Tzafon Medical Center  Poriya Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31815e4122"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.10.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.10.1203"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1825"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016\u20103026"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-3068"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-0012"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-052228"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-015-3199-y"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0087"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.317"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000000935"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17278"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2024-066600"},{"key":"e_1_2_11_16_1","unstructured":"NICE guidelines National Institute for Health and Care Excellence \u201cUrinary Tract Infection in Under 16s: Diagnosis and Management \u201dhttps:\/\/www.nice.org.uk\/guidance\/ng224."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03714-4"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T07:38:36Z","timestamp":1766389116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/apa.70143"],"URL":"https:\/\/doi.org\/10.1111\/apa.70143","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,20]]},"assertion":[{"value":"2025-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}