{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:42:42Z","timestamp":1790635362785,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the association between gonadotropin\u2010releasing hormone (GnRH)\u2010analogue use and adiposity change in girls with idiopathic central precocious puberty (CPP) or early puberty (EP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A systematic review was performed using PubMed, Embase, Scopus, PsycInfo and Cochrane. Primary studies reporting quantitative measures of adiposity in girls with idiopathic CPP\u2010EP who received GnRH\u2010analogues were included. A meta\u2010analysis was performed, with subgroup analyses based on baseline body mass index (BMI) and GnRH\u2010analogue type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 46 studies with 3606 girls who received GnRH\u2010analogues. BMI\u2010standard deviation scores (SDS) increased significantly within 2\u2009years (0.17, 95% CI 0.12\u20130.23) but not beyond 2\u2009years of therapy. Between the start and end of therapy, girls with normal BMI at baseline experienced a significant increase in BMI\u2010SDS (0.32, 95% CI 0.22\u20130.42) compared to those with overweight or obesity (BMI\u2010SDS \u22120.03, 95% CI \u22120.09 to 0.02). Leuprorelin use was associated with an increase in BMI\u2010SDS during therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GnRH\u2010analogue use in girls with CPP\u2010EP was associated with a transient increase in BMI\u2010SDS during, but not beyond therapy. Girls with normal BMI at baseline had a higher risk of experiencing significant increases in BMI\u2010SDS during therapy. BMI monitoring and anticipatory guidance for weight are recommended for those receiving GnRH\u2010analogues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70145","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T06:35:15Z","timestamp":1747982115000},"page":"2160-2181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Systematic Review on the Increase in Body Mass Index Percentiles in Girls With Central Precocious Puberty Receiving Gonadotropin\u2010Releasing Hormone Analogues"],"prefix":"10.1111","volume":"114","author":[{"given":"Natasha Yixuan","family":"Ong","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6310-2978","authenticated-orcid":false,"given":"Zera 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