{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:39:30Z","timestamp":1781174370589,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Cardiorespiratory events such as apnea, bradycardia and hypoxemia are common in preterm infants and may contribute to an impaired neurodevelopmental outcome. We hypothesised a significant reduction in the incidence of hypoxemia, bradycardia and gastric residuals in the prone position.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this monocentric, prospective, randomised, two\u2010arm crossover trial, at a tertiary university hospital, 48 preterm infants with a gestational age of &lt;\u200932\u2009weeks and a postmenstrual age of &lt;\u200934\u2009weeks were randomised to either a prone\u2013supine or a supine\u2013prone sequence of cardiorespiratory monitoring over a period of 24\u2009h. The primary outcome parameter was the cumulative frequency of hypoxemias and bradycardias; secondary parameters comprised evaluation of basal parameters, hypoxemias, bradycardias and the amount of gastric residuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cumulative frequency of hypoxemias and bradycardias and the number of severe hypoxemias (peripheral oxygen saturation [SpO\n                      <jats:sub>2<\/jats:sub>\n                      ] &lt;\u200980%) were halved in the prone position (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Median basal SpO\n                      <jats:sub>2<\/jats:sub>\n                      was significantly higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and gastric residuals were significantly lower (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0002) in the prone position. The frequency of apneas (&gt;\u200910\u2009s) was significantly increased in the prone position (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Prone positioning of preterm infants significantly reduces the cumulative frequency of hypoxemias and bradycardias, severe hypoxemias and gastric residuals while increasing basal SpO\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70153","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T08:53:46Z","timestamp":1748249626000},"page":"2643-2650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prone Positioning Was Associated With Less Hypoxemic Events and Improved Feeding Tolerance in Preterm Infants"],"prefix":"10.1111","volume":"114","author":[{"given":"Bettina","family":"Bohnhorst","sequence":"first","affiliation":[{"name":"Department of Pediatric Pneumology, Allergology and Neonatology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Lutz","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-6251","authenticated-orcid":false,"given":"Sabine","family":"Pirr","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology, Allergology and Neonatology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Peter","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology, Allergology and Neonatology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-3347","authenticated-orcid":false,"given":"Carolin","family":"B\u00f6hne","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology, Allergology and Neonatology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.164"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097446"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.8841"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.1.29"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.11124\/01938924\u2010200907070\u201000001"},{"key":"e_1_2_13_7_1","unstructured":"C. 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