{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:44:07Z","timestamp":1782906247867,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>A minority of patients with coeliac disease have mucosal pathology limited to the duodenal bulb. We aimed to describe the baseline characteristics of isolated duodenal bulb coeliac disease in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective multicentre study of paediatric patients diagnosed with coeliac disease, based on biopsies obtained separately from the duodenal bulb and distal duodenum, we evaluated the demographic, anthropometric, clinical, associated diseases and coeliac serology characteristics of the patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 586 children diagnosed with coeliac disease, 459 (78%) were classified as classic and 127 (22%) as isolated duodenal bulb coeliac disease\u2014376 (64.2%) were female and the median age was 7\u2009years (IQR 5\u201311). In multivariate logistic regression, scalloping of the duodenum (55.1% vs. 17.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, OR 4.7, 95% CI 2.8\u20138), growth impairment (9.8% vs. 9.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012, OR 2.7, 95% CI 1.4\u20135.5) and baseline anti\u2010tissue transglutaminase levels &gt; 10 upper limit of norm (71.5% vs. 29.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, OR 4.5, 95% CI 2.8\u20137.2) were associated with a higher probability of having classic coeliac disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lack of growth impairment, anti\u2010tissue transglutaminase levels &lt;10 upper limit of norm and lack of duodenal scalloping are predictive of isolated duodenal bulb involvement, making duodenal bulb biopsies even more important during esophagogastroduodenoscopy for the diagnosis of Celiac disease. [Correction added on 08 September 2025, after first online publication: The preceding sentence was corrected.]<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70169","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T08:28:31Z","timestamp":1749284911000},"page":"2697-2701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Characteristics of Isolated Duodenal Bulb Coeliac Disease in Children: A Multicentre Retrospective Study"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-8863","authenticated-orcid":false,"given":"Eyal","family":"Zifman","sequence":"first","affiliation":[{"name":"The Pediatric Gastroenterology Unit Meir Medical Center  Kfar\u2010Saba Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"Berliand","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Kaplan Medical Center  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bar","family":"Sofer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Technion  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Kori","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Kaplan Medical Center  Rehovot Israel"},{"name":"Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7634-5310","authenticated-orcid":false,"given":"Firas","family":"Rinawi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Technion  Haifa Israel"},{"name":"Pediatric Gastroenterology Unit Emek Medical Centre  Afula 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