{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T09:42:16Z","timestamp":1763804536363,"version":"3.45.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the occurrence of spontaneous intestinal perforation (SIP) in &lt;\u200928\u2009weeks' gestational age (GA) infants exposed to early low\u2010dose hydrocortisone (ELH) to reduce the risk of bronchopulmonary dysplasia (BPD). Additionally, the risk of SIP was assessed in infants exposed to early concomitant treatment with ibuprofen for persistent ductus arteriosus (PDA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational study in a tertiary neonatal centre preceding and following hydrocortisone implementation. Exposed and non\u2010exposed infants were compared after matching on delivery mode, multiple pregnancy, GA, birthweight, sex and using multivariate logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 653 infants, 259 (40%) had been exposed to hydrocortisone, and 210 from each group could be paired. Exposed infants had a higher rate of SIP (8.1% vs. 2.9%, OR [95% CI] 2.99 [1.15\u20137.74]). Early ibuprofen was provided to 110 exposed (52%) and 105 nonexposed (50%). The rate of SIP was higher in exposed infants cotreated with ibuprofen (11.8% vs. 3.8%, OR 3.38 [1.07\u201310.73]). Logistic regression analysis in the whole cohort confirmed the risk of SIP in infants exposed to concomitant treatment (OR [95% CI] 2.93 [1.24\u20136.93]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early concomitant treatment with ELH and ibuprofen is associated with an increased risk of SIP in infants born &lt;\u200928\u2009weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70175","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T08:23:28Z","timestamp":1749630208000},"page":"2856-2863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous Intestinal Perforation in Extremely Premature Infants Exposed to Early Low\u2010Dose Hydrocortisone"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1360-7915","authenticated-orcid":false,"given":"Gilles","family":"Cambonie","sequence":"first","affiliation":[{"name":"Department of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier  Montpellier France"},{"name":"Pathogenesis and Control of Chronic Infection, INSERM UMR 1058 University of Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anais","family":"Jouffrey","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Tessier","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Lapeyronie Hospital, Montpellier University Hospital Centre, University of Montpellier  Montpellier France"},{"name":"Institute Desbrest of Epidemiology and Public Health, INSERM UMR 1302 University of Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9mentine","family":"Combes","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Polito","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Department of Woman, Child, and Adolescent Medicine Geneva University Hospital  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6485-7634","authenticated-orcid":false,"given":"Arthur","family":"Gavotto","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier  Montpellier France"},{"name":"PhyMedExp, CNRS, INSERM University of Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2020.09.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211782"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1072\u20107515(02)01344\u20103"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17069"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005099"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16762"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001146.pub6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.2.320"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004\u20101159"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.12.040"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000098168"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)00202\u20106"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.10.004"},{"key":"e_1_2_9_15_1","first-page":"F154","article-title":"Hydrocortisone Treatment for Severe Evolving Bronchopulmonary Dysplasia and Cerebral Haemodynamics","volume":"94","author":"Cambonie G.","year":"2009","journal-title":"Archives of Disease in Childhood. 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