{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T11:41:51Z","timestamp":1763811711466,"version":"3.45.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Maternal age has increased steadily worldwide over the last few decades. This study aimed to investigate how different degrees of advanced maternal were associated with adverse neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A nationwide register\u2010based study was conducted using the Swedish Medical Birth Register. This comprised all singleton births to women aged 35\u2009years plus from 2010 to 2022. The women were divided into three groups based on maternal age: 35\u201339 was the reference group, and 40\u201344 and 45\u2009years plus were the advanced and very advanced maternal age groups, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We studied 312\u2009221 singleton pregnancies. There were increased odds risks (95% confidence intervals) for infants born to women aged 40\u201344 (17.8%) and 45\u2009years plus (1.1%), compared to those aged 35\u201339. These included stillbirths at 1.27 (1.12\u20131.45) and 1.80 (1.24\u20132.61) and infants being small for gestational age at 1.26 (1.19\u20131.33) and 1.46 (1.22\u20131.75). Risks for preterm birth, Apgar scores below seven at 5\u2009min, and hypoglycaemia also increased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Severe adverse neonatal outcomes were uncommon in Sweden but were higher in the advanced and very advanced maternal age groups than the younger reference group. Healthcare providers make women more aware of the risks of postponed childbearing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70185","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T01:55:35Z","timestamp":1750643735000},"page":"2893-2899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neonatal Outcomes Among Infants of Mothers With Advanced Maternal Age: A National Cohort Study"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3721-8271","authenticated-orcid":false,"given":"S.","family":"Voss","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-3811","authenticated-orcid":false,"given":"A.","family":"Josefsson","sequence":"additional","affiliation":[{"name":"Division of Children's and Women's Health Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6396-3930","authenticated-orcid":false,"given":"C.","family":"Ek\u00e9us","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,22]]},"reference":[{"unstructured":"\u201cThe Structure of Families\u2014Statistics on Age of Mothers at Childbirth and Age\u2010Specific Fertility \u201dFinancial Assistance of the European Union (2023) https:\/\/www.oecd.org\/els\/soc\/SF_2_3_Age_mothers_childbirth.pdf.","key":"e_1_2_11_2_1"},{"unstructured":"\u201cPopulation Statistics at Regional Level \u201dEurostat (2024) https:\/\/ec.europa.eu\/eurostat\/statistics\u2010explained\/index.php?title=Population_statistics_at_regional_level.","key":"e_1_2_11_3_1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_4_1","DOI":"10.1111\/aogs.14064"},{"doi-asserted-by":"publisher","key":"e_1_2_11_5_1","DOI":"10.1111\/j.1600-0412.2011.01335.x"},{"unstructured":"\u201cStatistik Om Graviditeter F\u00f6rlossningar Och Nyf\u00f6dda Barn 2022 \u201dSocialstyrelsen. Report No.: 2023\u201012\u20138867 (2023) https:\/\/www.socialstyrelsen.se\/globalassets\/sharepoint\u2010dokument\/artikelkatalog\/statistik\/2023\u201012\u20108867.pdf.","key":"e_1_2_11_6_1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_7_1","DOI":"10.1016\/j.fertnstert.2014.09.037"},{"doi-asserted-by":"publisher","key":"e_1_2_11_8_1","DOI":"10.1016\/j.ajogmf.2023.100885"},{"doi-asserted-by":"publisher","key":"e_1_2_11_9_1","DOI":"10.1002\/ijgo.14100"},{"doi-asserted-by":"publisher","key":"e_1_2_11_10_1","DOI":"10.20344\/amp.11057"},{"unstructured":"Socialstyrelsen \u201cStatistikdatabaser\u2014F\u00f6rlossningsstatistik\u2014Resultat \u201d(2024) https:\/\/sdb.socialstyrelsen.se\/if_mfr_004\/resultat.aspx.","key":"e_1_2_11_11_1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_12_1","DOI":"10.1371\/journal.pone.0186287"},{"doi-asserted-by":"publisher","key":"e_1_2_11_13_1","DOI":"10.1055\/s-0039-1694775"},{"doi-asserted-by":"publisher","key":"e_1_2_11_14_1","DOI":"10.1093\/ije\/dyac211"},{"doi-asserted-by":"publisher","key":"e_1_2_11_15_1","DOI":"10.1186\/s12884-019-2239-1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_16_1","DOI":"10.1007\/s10654-022-00947-5"},{"doi-asserted-by":"publisher","key":"e_1_2_11_17_1","DOI":"10.1152\/ajpheart.00045.2019"},{"doi-asserted-by":"publisher","key":"e_1_2_11_18_1","DOI":"10.1097\/AOG.0000000000000062"},{"doi-asserted-by":"publisher","key":"e_1_2_11_19_1","DOI":"10.1210\/er.2018-00083"},{"doi-asserted-by":"publisher","key":"e_1_2_11_20_1","DOI":"10.1016\/S0140-6736(23)00354-9"},{"doi-asserted-by":"publisher","key":"e_1_2_11_21_1","DOI":"10.1093\/aje\/kwx177"},{"doi-asserted-by":"publisher","key":"e_1_2_11_22_1","DOI":"10.1515\/jpm-2021-0298"},{"doi-asserted-by":"publisher","key":"e_1_2_11_23_1","DOI":"10.1056\/NEJMoa1915075"},{"doi-asserted-by":"publisher","key":"e_1_2_11_24_1","DOI":"10.1542\/peds.2015-2651"},{"unstructured":"Socialstyrelsen \u201cEn Indikatorbaserad Uppf\u00f6ljning F\u00f6r S\u00e4ker V\u00e5rd \u201d1\u2013230. Report No.: 2021\u20139\u20137552 (2021) https:\/\/www.socialstyrelsen.se\/globalassets\/sharepoint\u2010dokument\/artikelkatalog\/ovrigt\/2021\u20109\u20107552.pdf.","key":"e_1_2_11_25_1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_26_1","DOI":"10.1136\/bmj.k207"},{"doi-asserted-by":"publisher","key":"e_1_2_11_27_1","DOI":"10.1016\/j.ejogrb.2017.01.008"},{"doi-asserted-by":"publisher","key":"e_1_2_11_28_1","DOI":"10.1186\/s12884-021-03718-4"},{"doi-asserted-by":"publisher","key":"e_1_2_11_29_1","DOI":"10.1007\/s00404-014-3469-0"},{"doi-asserted-by":"publisher","key":"e_1_2_11_30_1","DOI":"10.1016\/j.fertnstert.2016.06.021"},{"doi-asserted-by":"publisher","key":"e_1_2_11_31_1","DOI":"10.1038\/s41598-020-66774-4"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.70185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T09:39:05Z","timestamp":1763804345000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.70185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,22]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/apa.70185"],"URL":"https:\/\/doi.org\/10.1111\/apa.70185","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"type":"print","value":"0803-5253"},{"type":"electronic","value":"1651-2227"}],"subject":[],"published":{"date-parts":[[2025,6,22]]},"assertion":[{"value":"2025-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}