{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:39:19Z","timestamp":1768433959003,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Determination of faecal gluten immunogenic peptides (f\u2010GIP) has recently been proposed as new noninvasive method to detect gluten intake in celiac disease (CD). Our aim was to evaluate the use of f\u2010GIP for the adherence to gluten\u2010free diet (GFD) and to compare this new marker with traditional methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled both newly diagnosed cases and children in follow\u2010up with CD. Adherence to the GFD was assessed using the Biagi score, IgA anti\u2010transglutaminase (tTG IgA) and f\u2010GIP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010one CD children, 40.8% new diagnosis and 59.2% in follow\u2010up, were enrolled. Significant differences were found in the levels of faecal GIP between new diagnosis and follow up (median 185.7\u2009ng\/mL, IQR 67.8\u2013318.8\u2009ng\/mL and 16.6\u2009ng\/mL, IQR 6.9\u201361\u2009ng\/mL respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A significant direct correlation was found between faecal GIP and tTG IgA in the total cohort of enrolled patients (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the follow up group, 21.4% tested positive for GIP and, of these GIP\u2009+\u2009patients, 78% had a high Biagi score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data shows that faecal GIP offers a precise assessment of even occasional exposure to gluten and suggests it might represent a less invasive instrument to check dietary adherence compared to traditional methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70187","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T09:09:37Z","timestamp":1750410577000},"page":"2885-2892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Testing for Faecal Gluten Immunogenic Peptides: Is It Useful to Evaluate Adherence to Gluten\u2010Free Diet?"],"prefix":"10.1111","volume":"114","author":[{"given":"Sabrina","family":"Cenni","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine University of Campania \u2018Luigi Vanvitelli\u2019  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Casertano","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialist Surgery University of Campania \u2018Luigi Vanvitelli\u2019  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"D'Addio","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialist Surgery University of Campania \u2018Luigi Vanvitelli\u2019  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Pacella","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Naples \u2018Federico II\u2019  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Tolone","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialist Surgery University of Campania \u2018Luigi Vanvitelli\u2019  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, Section of Pediatrics University of Naples \u2018Federico II\u2019  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Staiano","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, Section of Pediatrics University of Naples \u2018Federico II\u2019  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-7305","authenticated-orcid":false,"given":"Erasmo","family":"Miele","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, Section of Pediatrics University of Naples \u2018Federico II\u2019  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Strisciuglio","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialist Surgery University of Campania \u2018Luigi Vanvitelli\u2019  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9010046"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2016.01.021"},{"key":"e_1_2_12_4_1","first-page":"305","article-title":"Compliance to a Gluten\u2010Free Diet in Adolescents or, \u2018What Do 300 Coeliac Adolescents Eat Every Day?\u2019","volume":"29","author":"Greco L.","year":"1997","journal-title":"Italian Journal of Gastroenterology and Hepatology"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9090929"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101424"},{"key":"e_1_2_12_7_1","first-page":"241","article-title":"Quality of Life in Coeliac Disease Is Determined by Perceived Degree of Difficulty Adhering to a Gluten\u2010Free Diet, Not the Level of Dietary Adherence Ultimately Achieved","volume":"20","author":"Barratt S. 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