{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T06:39:36Z","timestamp":1788503976483,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Acquired Idiopathic purpura fulminans is a rare pathology caused by anti\u2010protein S antibodies. We have conducted a literature review focusing on the most recent developments in diagnosis and management. Diagnosis is based on the demonstration of typical necrotic purpura lesions on the legs. Treatment must be initiated without delay by infusion of fresh frozen plasma, plasmapheresis, or infusion of immunoglobulins, and curative anticoagulation. The challenge of limiting the incidence of serious complications can be met by disseminating simple diagnostic and treatment keys to paediatricians, with particular emphasis on recognising typical skin lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70193","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T09:38:29Z","timestamp":1750671509000},"page":"2511-2517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Post\u2010Viral Acquired Idiopathic Purpura Fulminans Caused by Anti\u2010Protein S Antibodies"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8793-4903","authenticated-orcid":false,"given":"Alexandre","family":"Theron","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Univ Montpellier, CHU Montpellier  Montpellier France"},{"name":"Resources and Competence Center for 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