{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:50:38Z","timestamp":1791384638438,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of the study was to assess growth patterns in a national cohort of children aged 0\u201317.9\u2009years diagnosed with acute lymphoblastic leukaemia (ALL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records at the four tertiary paediatric oncology hospitals in Norway were used for retrospective data collection. Anthropometrics were collected for patients diagnosed between 1 January 2008 and 31 December 2018, weekly, or as soon after as available, and followed up for 10\u2009years after diagnosis. Z\u2010scores were collected from the growth curve function in the medical record software and compared to the Norwegian reference population. Generalised additive mixed model was used for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis included 375 paediatric ALL patients. Data displayed an initial weight loss (z\u2010score from 0.00 to \u22120.25) and a stagnation in height growth (z\u2010score from 0.20 to \u22120.55). Throughout treatment and into remission, weight and body mass index stabilised significantly above the average healthy population (z\u2010score: 0.30 and 0.55 respectively). Height was nonsignificantly different in remission compared to the general population (z\u2010score: \u22120.15).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Weight gain, and BMI increase, occurred earlier than previously reported. Height was negatively affected by treatment. Monitoring of nutritional status, nutritional support efforts and physical activity is important throughout treatment to prevent unwanted and avoidable fluctuations in growth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70194","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T08:50:01Z","timestamp":1751014201000},"page":"2935-2943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Increase in Weight Is Seen During Treatment for Paediatric Acute Lymphoblastic Leukaemia\u2014A Retrospective Analysis of Medical Records"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7615-0086","authenticated-orcid":false,"given":"H\u00e5kon","family":"Endal","sequence":"first","affiliation":[{"name":"Institute of Health and Care Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn Helge","family":"Handeg\u00e5rd","sequence":"additional","affiliation":[{"name":"Regional Centre for Child and Youth Mental Health and Child Welfare UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine Nordeng","family":"Mellem","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Andrejeva","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga Maria Rinvoll","family":"Johannsdottir","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bendik","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology, St. Olavs Hospital Trondheim University Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trond","family":"Fl\u00e6gstad","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, UiT The Arctic University of Norway The University Hospital of Northern Norway Division for Paediatric Haematology and Oncology  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger P.","family":"Landsem","sequence":"additional","affiliation":[{"name":"Institute of Health and Care Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31080"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35338"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvad139"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqx006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31599"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2019.1577980"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29614"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4094\/chnr.2023.29.4.280"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2022.10.021"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6588"},{"key":"e_1_2_11_12_1","unstructured":"Nordic Sociecty of Paediatric Haematology and Oncology NOPHO ALL2008 [Internet]. 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