{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:34:29Z","timestamp":1767897269335,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Bumetanide, a diuretic, influences neuronal chloride homeostasis and potentially restores GABAergic inhibition and neuronal signalling balance. This mechanism may contribute to improvements in autism\u2010related symptoms. The present study builds on the preclinical research and on previous clinical research on bumetanide treatment for children with autism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifteen children (10 boys, 5 girls), aged 4\u201312\u2009years with a clinically confirmed autism diagnosis, with and without intellectual disability and with and without ADHD were enrolled in this 9\u2010month randomised waitlist\u2010control study. Participants were randomly assigned to either begin bumetanide treatment immediately or wait 3 months before starting. Parents completed rating scales assessing symptoms, behaviours and functioning at baseline and after 3, 6 and 9 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two children had to be excluded in the first treatment period with bumetanide due to emerging behavioural problems. Of the remaining 13, 4 discontinued after the 4\u20136\u2009months period with bumetanide, and 9 completed the full 9\u2010month study. According to parent reports, 4 of these 9 children experienced significant clinical improvements, leading parents to opt for continued bumetanide treatment for their child after study completion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This small, waitlist\u2010control study provides further support that bumetanide may have beneficial effects for some children with autism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70204","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T07:58:31Z","timestamp":1750924711000},"page":"2985-2992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bumetanide Treatment in 15 Children With Autism: A Randomised Waitlist\u2010Control Study"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4516-7747","authenticated-orcid":false,"given":"Elisabeth","family":"Fernell","sequence":"first","affiliation":[{"name":"Gillberg Neuropsychiatry Centre University of Gothenburg  Gothenburg Sweden"},{"name":"Child Neuropsychiatry Clinic Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Landberg","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Miniscalco","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Fagerudd","sequence":"additional","affiliation":[{"name":"Child Neuropsychiatry Clinic Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob \u00c5sberg","family":"Johnels","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Education and Special Education University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Johnson","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre University of Gothenburg  Gothenburg Sweden"},{"name":"Child Neuropsychiatry Clinic Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouchine","family":"Hadjikhani","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre University of Gothenburg  Gothenburg Sweden"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8848-1934","authenticated-orcid":false,"given":"Christopher","family":"Gillberg","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre University of Gothenburg  Gothenburg Sweden"},{"name":"Child Neuropsychiatry Clinic Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"The Autisms","author":"Gillberg C.","year":"2012"},{"key":"e_1_2_11_3_1","volume-title":"The ESSENCE of Autism and Other Neurodevelopmental Conditions. 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