{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:32:34Z","timestamp":1776814354184,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To describe the epidemiology and primary diagnoses of previously healthy children aged 3\u201359\u2009months who presented to paediatric emergency departments (PEDs) with a positive blood culture following the introduction of the publicly funded 13\u2010valent pneumococcal conjugate vaccine (PCV13).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicentre, cross\u2010sectional, retrospective registry study in seven PEDs between 2017 and 2022. The findings were compared with those of a similar registry from 2011 to 2016.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the funded PCV13 period, 278 patients were recorded. The most frequently isolated bacteria were\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                      <\/jats:styled-content>\n                      (36.6%),\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Escherichia coli<\/jats:italic>\n                      <\/jats:styled-content>\n                      (12.6%), and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Streptococcus pyogenes<\/jats:italic>\n                      <\/jats:styled-content>\n                      (9.4%) [Correction added on 7 August 2025, after first online publication: The percentage for Streptococcus pyogenes was corrected from (29.4%) to (9.4%).]. The most common diagnosis was focal infection (54.3%), followed by bacteremia without a focus of infection (26.6%), and severe invasive bacterial infection (19.1%). Poor outcomes were observed in 29.8% of patients. The most common serotypes during the funded PCV13 period were 10A, 24, and 8, none of which are included in PCV13.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                      <\/jats:styled-content>\n                      remained the leading cause of bacteremia in previously healthy children aged 3\u201359\u2009months, with a predominance of non\u2010vaccine serotypes. Although half of the patients had a localised infection, a substantial proportion developed severe invasive bacterial infections. Poor outcomes occurred in one out of every three to four invasive bacterial infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70217","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T14:58:34Z","timestamp":1752159514000},"page":"3043-3052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Streptococcus pneumoniae<\/i>\n                    Remains Leading Cause of Bacteremia in Children Despite 13\u2010Valent Pneumococcal Conjugate Vaccine Introduction"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2895-6282","authenticated-orcid":false,"given":"Mar\u00eda","family":"Garrido Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Pediatric Emergency Department Hospital Infantil Universitario Ni\u00f1o Jes\u00fas  Madrid 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Verdaguer","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Corporaci\u00f3 Sanitari Parc Taul\u00ed  Sabadell Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngela","family":"Hurtado Mingo","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Virgen del Roc\u00edo  Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-6068","authenticated-orcid":false,"given":"Ar\u00edstides","family":"Rivas Garc\u00eda","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1016-9472","authenticated-orcid":false,"given":"Iris","family":"Collazo Vallduriola","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital de Matar\u00f3  Matar\u00f3 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5391-2423","authenticated-orcid":false,"given":"Iker","family":"Gangoiti","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Cruces  Barakaldo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Velasco","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Corporaci\u00f3 Sanitari Parc Taul\u00ed  Sabadell Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"de la Torre Esp\u00ed","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Infantil Universitario Ni\u00f1o Jes\u00fas  Madrid Spain"},{"name":"Instituto Investigaci\u00f3n Sanitaria Hospital La Princesa  Madrid 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