{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:16:55Z","timestamp":1788959815539,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>During perinatal transition, breathing effort in preterm infants is largely inefficient. In the current study, we assessed the feasibility of synchronised non\u2010invasive positive pressure ventilation (S\u2010NIPPV) in very preterm infants as primary respiratory support in the delivery room.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single\u2010center prospective feasibility study at T\u00fcbingen University Hospital. Preterm infants with a gestational age (GA) between 26 and 32\u2009weeks received S\u2010NIPPV during the first 10\u2009min after birth. Synchronisation was achieved using a Graseby capsule; spontaneous breaths were detected by respiratory inductance plethysmography (RIP). Primary outcome was synchronisation rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten preterm infants with a median GA of 28.8\u2009weeks (IQR 27.6\u201330.4) and a birth weight of 1028\u2009g (819\u20131213) were included. S\u2010NIPPV was started within 44 (41\u201373) seconds after arrival on the resuscitaire. Synchrony rate was 68% (56\u201376) despite infants being handled significantly and 33% (27\u201340) of the time interventions were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>S\u2010NIPPV as primary respiratory support after birth is feasible with reasonable synchrony, even though infants are frequently stimulated and handled. Future studies are needed to confirm the results of this small pilot study and to determine the effect of S\u2010NIPPV on physiological and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      Feasibility and Reliability of Synchronized Non\u2010invasive Intermittent Positive Pressure Ventilation in Preterm Infants After Birth (SenSyNoPP);\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT05399914\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70220","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:00:17Z","timestamp":1752728417000},"page":"3159-3165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synchronised Non\u2010Invasive Intermittent Positive Pressure Ventilation in Very Preterm Infants After Birth: A Feasibility Study"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6441-0366","authenticated-orcid":false,"given":"Paul\u2010Philipp","family":"Warth","sequence":"first","affiliation":[{"name":"Neonatology University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1496-2625","authenticated-orcid":false,"given":"Christoph Martin","family":"R\u00fcegger","sequence":"additional","affiliation":[{"name":"Newborn Research, Department of Neonatology University Hospital and University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-652X","authenticated-orcid":false,"given":"Vincent David","family":"Gaertner","sequence":"additional","affiliation":[{"name":"Division of Neonatology Dr von Hauner Children's Hospital, LMU Hospital, Ludwig\u2010Maximilian\u2010Universit\u00e4t  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Braun","sequence":"additional","affiliation":[{"name":"Fritz Stephan GmbH  Gackenbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-1968","authenticated-orcid":false,"given":"Kriszta","family":"Molnar","sequence":"additional","affiliation":[{"name":"Neonatology University Hospital T\u00fcbingen  T\u00fcbingen 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