{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T16:19:22Z","timestamp":1762791562071,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the potential of the transmittance mode of time\u2010resolved near\u2010infrared spectroscopy, in which the source and detector probes are placed on the bilateral temporal region of the head, compared with the conventional reflectance mode in extremely low\u2010birth\u2010weight (ELBW) infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Differences in cerebral tissue oxygen saturation (StO\n                      <jats:sub>2<\/jats:sub>\n                      ) and cerebral blood volume (CBV) between the two modes were evaluated. Linear regression was performed to investigate contributing factors to StO\n                      <jats:sub>2<\/jats:sub>\n                      and CBV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010nine ELBW infants (median gestational age, 24.9\u2009weeks; mean birthweight, 672\u2009g), including nine intraventricular haemorrhage (IVH) cases, were evaluated at a median of 14.0\u2009days of age. StO\n                      <jats:sub>2<\/jats:sub>\n                      and CBV values were significantly lower in the transmittance mode than in the reflectance mode. IVH was a significant contributor to StO\n                      <jats:sub>2<\/jats:sub>\n                      and CBV. Two out of four cases with IVH grade 3 had larger ventricular dilations and showed outliers towards low StO\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The transmittance mode detected lower StO\n                      <jats:sub>2<\/jats:sub>\n                      in ELBW infants as compared to the reflectance mode, especially in IVH cases. This was either due to the optical effects of the IVH itself and\/or large dilated ventricles.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70245","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T12:49:05Z","timestamp":1753102145000},"page":"3222-3232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transmittance Mode of Time\u2010Resolved Near\u2010Infrared Spectroscopy for Monitoring Deeper Cerebral Tissues in Extremely Low\u2010Birth\u2010Weight Infants"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-1139","authenticated-orcid":false,"given":"Toshiyuki","family":"Imanishi","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Maternal, Fetus and Perinatal Center Saitama Children's Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wakako","family":"Sumiya","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Maternal, Fetus and Perinatal Center Saitama Children's Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Kanno","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Maternal, Fetus and Perinatal Center Saitama Children's Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Kanno","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Maternal, Fetus and Perinatal Center Saitama Children's Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Maternal, Fetus and Perinatal Center Saitama Children's Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Maternal, Fetus and Perinatal Center Saitama Children's Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049\u20103848(11)70032\u20109"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013\u20100372"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.114"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011506.pub2"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010018\u20100026\u20108"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-42876-7.00024-7"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1364\/ao.42.002881"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3023-4_50"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.1899184"},{"key":"e_1_2_14_11_1","first-page":"427","volume-title":"Oxygen Transport to Tissue","author":"Fujisaka S.","year":"2016"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/39\/8\/008"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000175638.98041.0E"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(78)80282\u20100"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.23.6.067003"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.8.4.045001"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17040"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2017.05.012"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010020\u201001189\u20105"},{"volume-title":"Neurology of the Newborn","year":"2008","author":"Volpe J. 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