{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:08:43Z","timestamp":1792084123571,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00179906"],"award-info":[{"award-number":["00179906"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study evaluated urinary calcium (Ca) and phosphorus (P) excretion in very low birth weight infants (\u2009&lt;\u20091500\u2009g, VLBW) without severe morbidity, treated with methylxanthines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty\u2010one VLBW infants were analysed. Urinary Ca and P and their creatinine ratios were measured biweekly until day 56. Serum parathyroid hormone (PTH), 25\u2010hydroxyvitamin D [25\u2010(OH)D], total Ca, P and alkaline phosphatase (ALP) were assessed. Bone densitometry was performed before discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 254 urine samples, urinary Ca and P excretion differed significantly from their creatinine ratios. Vitamin D status influenced urinary mineral excretion, likely via PTH regulation, but did not affect serum Ca, P, or ALP. Normative data were established only for infants with serum 25\u2010(OH)D &gt;\u200950\u2009nmol\/L. Due to age\u2010related variability, a single reference range was not possible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We provide age\u2010specific normative data for urinary Ca and P excretion in healthy VLBW infants with sufficient vitamin D. Urinary mineral excretion varies significantly with postnatal age, emphasising the need for individualised monitoring to prevent metabolic bone disease of prematurity. Vitamin D status is crucial for calcium\u2013phosphorus homeostasis, with sufficient levels linked to increased Ca excretion and relative P depletion from the 2\u2009month of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apa.70253","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T06:05:08Z","timestamp":1754114708000},"page":"3267-3278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Urinary Calcium and Phosphorus Excretion in Vitamin D\u2010Sufficient Preterm Infants: Establishing Age\u2010Specific Normative Data"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7359-9670","authenticated-orcid":false,"given":"Tomas","family":"Matejek","sequence":"first","affiliation":[{"name":"Department of Paediatrics Charles University in Prague, Faculty of Medicine Hradec Kralove  Hradec Kralove Czech Republic"},{"name":"Department of Paediatrics University Hospital Hradec Kralove  Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Pokorna","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Charles University in Prague, Faculty of Medicine Hradec Kralove  Hradec Kralove Czech Republic"},{"name":"Department of Paediatrics University Hospital Hradec Kralove  Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vojtech","family":"Drahy","sequence":"additional","affiliation":[{"name":"Department of Computer Science Czech Technical University in Prague, Faculty of Electrical Engineering  Prague Czech Republic"},{"name":"Computer Vision and Pattern Recognition Laboratory, Lappeenranta\u2010Lahti University of Technology LUT Department of Computational Engineering  Lappeenranta Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Zaloudkova","sequence":"additional","affiliation":[{"name":"Institute of Clinical Biochemistry and Diagnostics Faculty of Medicine Hradec Kralove  Hradec Kralove Czech Republic"},{"name":"Institute of Clinical Biochemistry and Diagnostics University Hospital Hradec Kralove  Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Palicka","sequence":"additional","affiliation":[{"name":"Institute of Clinical Biochemistry and Diagnostics Faculty of Medicine Hradec Kralove  Hradec Kralove Czech Republic"},{"name":"Institute of Clinical Biochemistry and Diagnostics University Hospital Hradec Kralove  Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylva","family":"Skalova","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Charles University in Prague, Faculty of Medicine Hradec Kralove  Hradec Kralove Czech Republic"},{"name":"Department of Paediatrics University Hospital Hradec Kralove  Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2020.101086"},{"key":"e_1_2_13_3_1","volume-title":"Rowitch D, Benitz WE","author":"Polin R. 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